Safety and effectiveness of acute intermittent hypoxia during a single treatment at different hypoxic severities

IF 1.9 4区医学 Q3 PHYSIOLOGY Respiratory Physiology & Neurobiology Pub Date : 2024-09-29 DOI:10.1016/j.resp.2024.104358

Cory M. Smith, Owen F. Salmon

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Abstract

Purpose

Examine the cardiovascular, muscular function, cognitive, and neural plastic responses to determine the safety and effectiveness of acute Intermittent hypoxia (AIH) at a low, high, and control fractional inspired oxygen (FiO₂) dosage

Methods

Thirteen human participants performed 30-min of AIH in 60-s intervals at FiO2’s of 0.21 (AIH₂₁), 0.15 (AIH₁₅), and 0.09 (AIH₉). Heart rate variability (root mean squared of successive differences; RMSSD), heart rate, oxygen saturation (SpO2), blood pressure, muscular strength, neuromuscular activation, cerebral hemodynamic responses, cognition, symptomology, and brain-derived neurotrophic factor (BDNF) responses were measured before (Pre-AIH), after (post-AIH), and at 20-min of recovery (Recovery-AIH)

Results

There were no differences between AIH protocols for heart rate, RMSSD, blood pressure, or SpO2. Muscular strength improved Post-AIH for AIH₁₅ (10 %) and AIH₉ (14 %) and remained elevated (6 %) at Recovery-AIH. Neuromuscular activation increased Pre-AIH to Post-AIH for AIH15 (10 %) and AIH₉ (11 %). Cerebral hemodynamic responses were not impacted between conditions. Both AIH₁₅ and AIH9 increased BDNF Post-AIH (62 %) and Recovery-AIH (63 %)

Conclusion

Acute intermittent hypoxia is generally safe and effective at producing neural plastic responses, but further examination of co-occurring cardiovascular diseases is needed. This study provides safety focused findings which will widen the adoption and refinement of AIH protocols

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不同缺氧严重程度下单次急性间歇性缺氧治疗的安全性和有效性

目的：检查心血管、肌肉功能、认知和神经可塑性反应，以确定在低、高和控制分数吸入氧（FiO2）剂量下进行急性间歇性缺氧（AIH）的安全性和有效性方法：13 名人类参与者在 FiO2 为 0.21（AIH21）、0.15（AIH15）和 0.09（AIH9）的条件下，以 60 秒为间隔进行了 30 分钟的 AIH。测量了心率变异性（连续差值的均方根；RMSSD）、心率、血氧饱和度（SpO2）、血压、肌肉力量、神经肌肉活化、脑血流动力学反应、认知、症状和脑源性神经营养因子（BDNF）反应，分别在治疗前（Pre-AIH）、治疗后（post-AIH）和恢复 20 分钟后（Recovery-AIH）进行结果：不同的 AIH 方案在心率、RMSSD、血压或 SpO2 方面没有差异。AIH15（10%）和 AIH9（14%）在恢复-AIH 后的肌肉强度有所提高，但在恢复-AIH 时仍保持较高水平（6%）。AIH15（10%）和 AIH9（11%）的神经肌肉激活从恢复前增加到恢复后。不同条件下的脑血流动力学反应没有受到影响。AIH15和AIH9都能在AIH后（62%）和恢复期AIH（63%）增加BDNF 结论：急性间歇性缺氧在产生神经可塑性反应方面通常是安全有效的，但还需要进一步检查并发的心血管疾病。本研究提供了以安全性为重点的研究结果，这将扩大急性间歇缺氧方案的采用范围并使其更加完善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.