Diffuse idiopathic skeletal hyperostosis is associated with greater complexity of coronary artery disease burden on coronary angiography.

IF 1.2 Q4 RHEUMATOLOGY Reumatismo Pub Date : 2024-10-01 DOI:10.4081/reumatismo.2024.1692

G Adami, S Zanon, A Fassio, G Pesarini, M Pighi, R Scarsini, D Tavella, M Rossini, D Gatti, F Ribichini

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引用次数: 0

Abstract

Objective: Diffuse idiopathic skeletal hyperostosis (DISH) is a common disorder characterized by ossification of tendons and ligaments. DISH has been largely associated with an increased risk of metabolic syndrome and type 2 diabetes. The objective of the present study is to investigate the role of DISH on the risk of coronary artery disease (CAD).

Methods: We conducted an observational cross-sectional study of patients without a history of rheumatic musculoskeletal diseases who underwent coronary angiography between March 2016 and April 2021. The SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery (SYNTAX) score was calculated based on coronary angiography images. DISH diagnosis was based on standard X-ray images and computed tomography scans (Resnick criteria). Demographic and clinical characteristics were retrieved from electronic medical records. Multinomial and binary logistic regression models were employed to determine the association between SYNTAX score (dependent variable) and DISH (independent variable).

Results: The study included 187 patients, 82.9% of whom were men, with valid radiological imaging. 83 (44.4%) patients had a confirmed radiological diagnosis of DISH. Diagnosis of DISH was associated with a higher SYNTAX score [adjusted odds ratio (aOR) 34.1, 95% confidence interval (CI) 1.41-79.2 p=0.049], independently from traditional cardiovascular risk factors. In patients aged <70 years, DISH was associated with a 7-fold higher risk of belonging to the highest category of SYNTAX (≥34), compared to non-DISH (aOR 7.23, 95% CI 1.08-48.4; p=0.041). The extension of vertebral calcification was significantly associated with SYNTAX score (r2 0.378, p<0.0001).

Conclusions: DISH diagnosis is common in patients at high risk of cardiovascular disease or with definitive CAD. DISH was independently associated with higher CAD complexity.

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弥漫性特发性骨骼发育不良与冠状动脉造影检查中冠状动脉疾病负担的复杂性有关。

目的：弥漫性特发性骨骼增生症（DISH）是一种以肌腱和韧带骨化为特征的常见疾病。DISH 在很大程度上与代谢综合征和 2 型糖尿病风险增加有关。本研究旨在探讨 DISH 对冠状动脉疾病（CAD）风险的影响：我们对 2016 年 3 月至 2021 年 4 月期间接受冠状动脉造影术的无风湿性肌肉骨骼疾病史患者进行了一项观察性横断面研究。根据冠状动脉造影图像计算了TAXus经皮冠状动脉介入治疗与心脏手术之间的SYNERGY（SYNTAX）评分。DISH 诊断基于标准 X 光图像和计算机断层扫描（Resnick 标准）。人口统计学和临床特征均来自电子病历。采用多项式和二元逻辑回归模型确定 SYNTAX 评分（因变量）与 DISH（自变量）之间的关联：研究共纳入 187 名患者，其中 82.9% 为男性，均有有效的放射成像。83名患者（44.4%）经放射学确诊为 DISH。DISH的诊断与较高的SYNTAX评分相关[调整后比值比（aOR）34.1，95% 置信区间（CI）1.41-79.2 p=0.049]，与传统的心血管风险因素无关。结论DISH诊断常见于心血管疾病高风险或明确患有CAD的患者。DISH 与较高的 CAD 复杂性独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reumatismo RHEUMATOLOGY-

CiteScore

2.10

自引率

7.10%

发文量

审稿时长

10 weeks

期刊介绍： Reumatismo is the official Journal of the Italian Society of Rheumatology (SIR). It publishes Abstracts and Proceedings of Italian Congresses and original papers concerning rheumatology. Reumatismo is published quarterly and is sent free of charge to the Members of the SIR who regularly pay the annual fee. Those who are not Members of the SIR as well as Corporations and Institutions may also subscribe to the Journal.