Cumulative Health Risk from Exposure Load (CHREL): Looking at multi-chemical exposures through the lens of biomonitoring guidance values

IF 2.9 3区 医学 Q2 TOXICOLOGY Toxicology letters Pub Date : 2024-09-27 DOI:10.1016/j.toxlet.2024.09.006
Jeff B. Willey , Chun Lei Liang , Tyler Pollock , Cheryl Khoury , Errol M. Thomson , Mike Walker , Annie St-Amand
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Abstract

Exposure load (EL) is an indicator of multiple chemical exposures based on human biomonitoring data. We used EL methodology and human biomonitoring health-based guidance values (HB2GVs) as exposure thresholds to create a new metric called Cumulative Health Risk from Exposure Load (CHREL). HB2GVs are derived by calculating the concentration of a biomarker consistent with a health protective exposure guidance value. CHREL analysis was conducted using Canadian Health Measures Survey (CHMS) cycle 3 and 4 biomonitoring data. Based on 18 chemicals, more than half of the Canadian population had an estimated CHRELTOTAL of 1 or more, indicative of chemical exposures potentially above selected exposure guidance values. Females had a significantly lower CHRELTOTAL compared to males, 12–19 year olds had a lower CHRELTOTAL compared to older age groups (significant compared to 40–59 year olds), and nonsmokers had a significantly lower CHRELTOTAL than smokers. Small segments of the population had a CHRELLIVER or a CHRELNERV of 1 or more, indicating exposures potentially above guideline levels for chemicals affecting the liver or nervous system. CHRELCANC was calculated based on 6 chemicals with HB2GVs derived for cancer endpoints. At the 10−5 risk level, most people had an estimated CHRELCANC of 3, indicative of multiple chemicals that may exceed negligible cancer risk. The most important contributors to exposures above HB2GVs were inorganic arsenic, mercury, acrylamide, xylenes, benzene and triclosan. Keeping certain assumptions, uncertainties and limitations in mind, the CHREL indicator can be used to obtain a picture of potential cumulative health risks from combined chemical exposures in a population, and as a comparative measure between subpopulations, including vulnerable subgroups.
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暴露负荷累积健康风险 (CHREL):从生物监测指导值的角度审视多种化学品暴露。
暴露负荷(EL)是基于人体生物监测数据的多种化学品暴露指标。我们使用 EL 方法和基于健康的指导值 (HB2GV) 作为暴露阈值,创建了一个名为 "暴露负荷累积健康风险"(CHREL)的新指标。HB2GV 是通过计算符合健康保护暴露指导值的生物标志物浓度得出的。CHREL 分析是利用加拿大健康测量调查 (CHMS) 第 3 和第 4 周期生物监测数据进行的。基于 18 种化学品,加拿大一半以上人口的估计 CHRELTOTAL 值为 1 或更高,表明化学品暴露可能超过选定的暴露指导值。女性的 CHRELTOTAL 值明显低于男性,12-19 岁人群的 CHRELTOTAL 值明显低于年龄较大的人群(明显低于 40-59 岁人群),非吸烟人群的 CHRELTOTAL 值明显低于吸烟人群。小部分人群的 CHRELLIVER 或 CHRELNERV 值达到或超过 1,表明暴露于影响肝脏或神经系统的化学品的程度可能高于指导水平。CHRELCANC 是根据 6 种化学品的 HB2GV 计算得出的癌症终点。在 10-5 风险水平下,大多数人的 CHRELCANC 估计值为 3,表明多种化学品的致癌风险可能超过可忽略不计的水平。无机砷、汞、丙烯酰胺、二甲苯、苯和三氯生是导致暴露量超过 HB2GVs 的最主要因素。在考虑到某些假设、不确定性和局限性的情况下,CHREL 指标可用于了解人口中化学品综合暴露的潜在累积健康风险,也可作为亚人群(包括易受伤害的亚人群)之间的比较指标。
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来源期刊
Toxicology letters
Toxicology letters 医学-毒理学
CiteScore
7.10
自引率
2.90%
发文量
897
审稿时长
33 days
期刊介绍: An international journal for the rapid publication of novel reports on a range of aspects of toxicology, especially mechanisms of toxicity.
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