Factors Contributing to In-Hospital Mortality in Dengue: Insights from National Surveillance Data in Mexico (2020-2024).

IF 2.8 4区医学 Q2 INFECTIOUS DISEASES Tropical Medicine and Infectious Disease Pub Date : 2024-09-03 DOI:10.3390/tropicalmed9090202

Eder Fernando Ríos-Bracamontes, Oliver Mendoza-Cano, Agustin Lugo-Radillo, Ana Daniela Ortega-Ramírez, Efrén Murillo-Zamora

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Abstract

This study aimed to identify the factors associated with all-cause in-hospital mortality in laboratory-confirmed dengue cases from 2020 to mid-2024. A nationwide retrospective cohort study was conducted in Mexico and data from 18,436 participants were analyzed. Risk ratios (RRs) and 95% confidence intervals (CIs), estimated using generalized linear regression models, were used to evaluate the factors associated with all-cause in-hospital mortality risk. The overall case-fatality rate was 17.5 per 1000. In the multiple model, compared to dengue virus (DENV) 1 infections, DENV-2 (RR = 1.81, 95% CI 1.15-2.86) and DENV-3 (RR = 1.87, 95% CI 1.19-2.92) were associated with increased mortality risk. Patient characteristics, such as increasing age (RR = 1.02, 95% CI 1.01-1.03), type 2 diabetes mellitus (RR = 2.07, 95% CI 1.45-2.96), and chronic kidney disease (RR = 3.35, 95% CI 2.03-5.51), were also associated with an increased risk of a fatal outcome. We documented the influence of both the virus and individual susceptibility on mortality risk, underscoring the need for a comprehensive public health strategy for dengue.

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导致登革热住院死亡率的因素：墨西哥国家监测数据的启示（2020-2024 年）》。

本研究旨在确定 2020 年至 2024 年中期实验室确诊登革热病例的全因住院死亡率的相关因素。在墨西哥开展了一项全国性的回顾性队列研究，分析了来自 18,436 名参与者的数据。采用广义线性回归模型估算的风险比（RRs）和 95% 置信区间（CIs）用于评估与全因住院死亡风险相关的因素。总病死率为17.5/1000。在多重模型中，与登革病毒（DENV）1感染相比，DENV-2（RR = 1.81，95% CI 1.15-2.86）和DENV-3（RR = 1.87，95% CI 1.19-2.92）与死亡风险增加有关。患者特征，如年龄增加（RR = 1.02，95% CI 1.01-1.03）、2 型糖尿病（RR = 2.07，95% CI 1.45-2.96）和慢性肾脏病（RR = 3.35，95% CI 2.03-5.51），也与死亡风险增加有关。我们记录了病毒和个人易感性对死亡风险的影响，强调了对登革热采取综合公共卫生战略的必要性。

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