Characterization of multiple human papillomavirus types in the human vagina following ovarian hormonal stimulation.

IF 4 3区医学 Q2 VIROLOGY Virology Journal Pub Date : 2024-09-27 DOI:10.1186/s12985-024-02507-7

Endrya do Socorro Foro Ramos, Roseane da Silva Couto, Tania Regina Tozetto-Mendoza, Pietro Bortoletto, Erick Matheus Garcia Barbosa, Noely Evangelista Ferreira, Iara M Linhares, Steven D Spandorfer, Antonio Charlys da Costa, Elcio Leal, Maria Cassia Mendes-Correa, Steven S Witkin

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Abstract

The objective of study was to characterize HPV in vaginal samples from women being seen at the Center for Reproductive Medicine and Infertility at Weill Cornell Medicine before and following ovarian stimulation. A total of 29 women made samples available for analysis by viral metagenomics. Eighteen women were HPV-positive, six (33.3%) at their initial visit and 15 (83.3%) following hormone stimulation (p = 0.0059). Pairwise comparison of nucleotide sequences and phylogenetic analysis showed the classification sequences into two genera: Alphapapillomavirus and Gammapapillomavirus. Sequences were from 8 HPV types: HPV 51 (n = 2), HPV 68 (n = 1), HPV 83 (n = 9), HPV 84 (n = 2), HPV 121 (n = 6), HPV 175 (n = 1) and HPV 190 (n = 1). Additionally, C16b and C30 likely represent new types. In summary, multiple HPV types are present in the vagina of reproductive age women and are induced by hormone used to stimulate ovulation.

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卵巢激素刺激后人体阴道内多种人类乳头瘤病毒的特征。

这项研究的目的是分析威尔-康奈尔医学中心生殖医学和不孕症中心就诊妇女在卵巢刺激前和刺激后阴道样本中 HPV 的特征。共有 29 名妇女提供了样本供病毒元基因组学分析。18名妇女的HPV呈阳性，其中6人（33.3%）在初次就诊时呈阳性，15人（83.3%）在激素刺激后呈阳性（P = 0.0059）。核苷酸序列的配对比较和系统发育分析表明，该分类序列分为两个属：Alphapapillomavirus和Gammapapillomavirus。序列来自 8 种 HPV 类型：HPV 51（n = 2）、HPV 68（n = 1）、HPV 83（n = 9）、HPV 84（n = 2）、HPV 121（n = 6）、HPV 175（n = 1）和 HPV 190（n = 1）。此外，C16b 和 C30 很可能是新的类型。总之，育龄妇女的阴道中存在多种类型的 HPV，并且会受到用于刺激排卵的激素的诱导。

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来源期刊

Virology Journal 医学-病毒学

CiteScore

7.40

自引率

2.10%

发文量

186

审稿时长

1 months

期刊介绍： Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.