Serum tumor markers (carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4, carbohydrate antigen 24-2, ferritin) and gastric cancer prognosis correlation.

IF 1.8 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY World Journal of Gastrointestinal Surgery Pub Date : 2024-09-27 DOI:10.4240/wjgs.v16.i9.2808

Jie-Wen Zhu, Ling-Zhen Gong, Qian-Wen Wang

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Abstract

Background: Gastric cancer is a kind of malignant tumor which is prevalent all over the world. Although some progress has been made in the treatment of gastric cancer, its prognosis is still not optimistic, so it is of great significance to find reliable prognostic indicators to guide the treatment and management of patients with gastric cancer.

Aim: To explore the relationship between serum levels of five biomarkers [carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA72-4, CA24-2, and ferritin] and prognosis in patients with gastric cancer.

Methods: This study included 200 patients with gastric adenocarcinoma, and conducted an in-depth analysis of their baseline characteristics, relationship between tumor markers and staging, and prognosis. The study found that CA19-9 has a significant correlation with tumor stage, the average levels of CA24-2, CEA, CA72-4 and ferritin were slightly increased disregarding the stage of tumor. Survival analysis showed that increases in CEA, CA19-9, CA24-2, and ferritin were all associated with shortened overall survival of patients. Further multivariate analysis revealed that elevated serum CA72-4 levels were an independent adverse prognostic factor.

Results: This study reveals that there is a significant correlation between the expression levels of serum tumor markers CEA, CA19-9, CA72-4, CA24-2 and ferritin in patients with gastric cancer and prognosis, and can be used as important indicators for prognostic evaluation of gastric cancer. In particular, markers that appear abnormally elevated initially may help identify gastric cancer patients with poor prognosis.

Conclusion: Serum CEA and CA19-9 play an important role in the prognosis assessment of gastric cancer, and are effective tools to guide clinical practice and optimize individualized treatment strategies for gastric cancer patients.

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血清肿瘤标志物（癌胚抗原、碳水化合物抗原 19-9、碳水化合物抗原 72-4、碳水化合物抗原 24-2、铁蛋白）与胃癌预后的相关性。

背景：胃癌是一种在全球普遍存在的恶性肿瘤。目的：探讨胃癌患者血清中五种生物标志物[癌胚抗原（CEA）、碳水化合物抗原（CA）19-9、CA72-4、CA24-2、铁蛋白]水平与预后的关系：该研究纳入了 200 名胃癌患者，对他们的基线特征、肿瘤标志物与分期的关系以及预后进行了深入分析。研究发现，CA19-9与肿瘤分期有显著相关性，CA24-2、CEA、CA72-4和铁蛋白的平均水平略有升高，与肿瘤分期无关。生存期分析表明，CEA、CA19-9、CA24-2 和铁蛋白的增加都与患者总生存期的缩短有关。进一步的多变量分析显示，血清 CA72-4 水平升高是一个独立的不良预后因素：本研究显示，胃癌患者血清肿瘤标志物 CEA、CA19-9、CA72-4、CA24-2 和铁蛋白的表达水平与预后有显著相关性，可作为胃癌预后评估的重要指标。尤其是最初出现异常升高的标志物可能有助于鉴别预后不良的胃癌患者：结论：血清 CEA 和 CA19-9 在胃癌预后评估中发挥着重要作用，是指导临床实践和优化胃癌患者个体化治疗策略的有效工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Gastrointestinal Surgery Multiple-

自引率

5.00%

发文量

111