Skin metabolism in obesity: A narrative review.

IF 3.8 3区 医学 Q2 CELL BIOLOGY Wound Repair and Regeneration Pub Date : 2024-11-01 Epub Date: 2024-09-24 DOI:10.1111/wrr.13223
Rubya Pereira Zaccaron, Carolini Mendes, Camila da Costa, Paulo Cesar Lock Silveira, Gislaine Tezza Rezin
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Abstract

Obesity is a complex multifactorial disease in which excess body fat triggers negative health effects. Systemically, obesity causes several changes, such as inflammation, oxidative stress, mitochondrial dysfunction and apoptosis; factors linked to the slow and incomplete epithelial regenerative process. Specifically, in the integumentary system, obesity causes an expansion of the skin's surface area and changes in collagen deposition. Molecular underpinnings of why obesity delays wound healing are still poorly understood. In addition to the primary role of dermal adipocytes in lipid storage and heat insulation, they also promote skin immunity, wound healing and hair follicle cycling. As a consequence of the cellular and dysfunctional adaptations of adipocytes, inflammatory immune alterations, alteration in the expression of proteins genes associated with the blood supply, altered collagen formation through fibroblast senescence and excessive degradation of extracellular matrix proteins are metabolic characteristics of the system in obesity that contribute to sustained inflammation and decreased mechanical resistance of the skin.

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肥胖症的皮肤代谢:叙述性综述。
肥胖症是一种复杂的多因素疾病,体内脂肪过多会对健康产生负面影响。从全身来看,肥胖会导致多种变化,如炎症、氧化应激、线粒体功能障碍和细胞凋亡;这些因素与缓慢而不完全的上皮再生过程有关。具体而言,肥胖会导致皮肤表面积扩大,胶原蛋白沉积发生变化。人们对肥胖为何会延迟伤口愈合的分子基础仍然知之甚少。真皮脂肪细胞的主要作用是储存脂质和隔热,除此之外,它们还能促进皮肤免疫、伤口愈合和毛囊循环。由于脂肪细胞的细胞适应性和功能失调,炎症性免疫改变、与血液供应相关的蛋白基因表达改变、成纤维细胞衰老导致胶原蛋白形成改变以及细胞外基质蛋白过度降解,这些都是肥胖症系统的代谢特征,导致炎症持续存在和皮肤机械阻力下降。
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来源期刊
Wound Repair and Regeneration
Wound Repair and Regeneration 医学-皮肤病学
CiteScore
5.90
自引率
3.40%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.
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