Clinical significance of the CALLY index in patients with gastric cancer undergoing gastrectomy.

IF 2.3 3区医学 Q2 SURGERY World Journal of Surgery Pub Date : 2024-11-01 Epub Date: 2024-09-30 DOI:10.1002/wjs.12357

Katsunobu Sakurai, Naoshi Kubo, Tsuyoshi Hasegawa, Junya Nishimura, Yasuhito Iseki, Takafumi Nishii, Toru Inoue, Masakazu Yashiro, Yukio Nishiguchi, Kiyoshi Maeda

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Abstract

Background: The aim of this study was to elucidate the clinical impact of the CALLY index in patients with gastric cancer (GC) undergoing gastrectomy.

Methods: Between January 2014 and December 2020, 617 patients who underwent gastrectomy for GC at the Osaka City General Hospital were enrolled in this study. The CALLY index was calculated using the following formula: [albumin (g/dL) × lymphocytes (/μl)]/[CRP (mg/dL) × 10⁴]. We compared the predictive value of four biomarkers [CALLY index, modified Glasgow prognostic score (mGPS), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR)] for short- and long-term outcomes and focused on the CALLY index to elucidate its clinical value.

Results: Receiver operating characteristic analysis showed that the area under the curve for the CALLY index was the highest among the four biomarkers. The 5-year overall survival (OS) and cancer-specific survival (CSS) rates in the low and the high CALLY groups were statistically significant. Multivariate analysis identified the CALLY index as an independent factor for OS and CSS but not NLR or PLR. The mGPS was an independent factor for OS but not for CSS in multivariate analysis. Regarding complications, only the CALLY index was an independent predictor of major complications (≧ Clavien-Dindo grade 3) in multivariate analysis but not others.

Conclusions: The CALLY index may have a clinical value in predicting OS, CSS, and major complications in GC patients undergoing gastrectomy.

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接受胃切除术的胃癌患者的 CALLY 指数的临床意义。

背景：本研究旨在阐明CALLY指数对接受胃切除术的胃癌患者的临床影响：本研究旨在阐明CALLY指数对接受胃切除术的胃癌（GC）患者的临床影响：方法：2014 年 1 月至 2020 年 12 月期间，大阪市立综合医院共招募了 617 名接受胃切除术的 GC 患者。CALLY 指数按以下公式计算：[白蛋白（g/dL）×淋巴细胞（/μl）]/[CRP（mg/dL）×104]。我们比较了四种生物标志物[CALLY指数、改良格拉斯哥预后评分（mGPS）、中性粒细胞-淋巴细胞比值（NLR）和血小板-淋巴细胞比值（PLR）]对短期和长期预后的预测价值，并重点研究了CALLY指数，以阐明其临床价值：接收者操作特征分析表明，CALLY指数的曲线下面积是四种生物标志物中最大的。低CALLY组和高CALLY组的5年总生存率（OS）和癌症特异性生存率（CSS）均有统计学意义。多变量分析发现，CALLY指数是影响OS和CSS的独立因素，但不是NLR或PLR。在多变量分析中，mGPS是影响OS的独立因素，但不是影响CSS的独立因素。关于并发症，在多变量分析中，只有CALLY指数是主要并发症（≧ Clavien-Dindo 3级）的独立预测因素，而其他并发症则不是：结论：CALLY指数在预测接受胃切除术的GC患者的OS、CSS和主要并发症方面可能具有临床价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Surgery 医学-外科

CiteScore

5.10

自引率

3.80%

发文量

460

审稿时长

3 months

期刊介绍： World Journal of Surgery is the official publication of the International Society of Surgery/Societe Internationale de Chirurgie (iss-sic.com). Under the editorship of Dr. Julie Ann Sosa, World Journal of Surgery provides an in-depth, international forum for the most authoritative information on major clinical problems in the fields of clinical and experimental surgery, surgical education, and socioeconomic aspects of surgical care. Contributions are reviewed and selected by a group of distinguished surgeons from across the world who make up the Editorial Board.