Extra-osseous Roles of the RANK-RANKL-OPG Axis with a Focus on Skeletal Muscle.

IF 4.3 2区医学 Current Osteoporosis Reports Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI:10.1007/s11914-024-00890-2

John Gostage, Paul Kostenuik, Katarzyna Goljanek-Whysall, Ilaria Bellantuono, Eugene McCloskey, Nicolas Bonnet

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Abstract

Purpose of review: This review aims to consolidate recent observations regarding extra-osseous roles of the RANK-RANKL-OPG axis, primarily within skeletal muscle.

Recent findings: Preclinical efforts to decipher a common signalling pathway that links the synchronous decline in bone and muscle health in ageing and disease disclosed a potential role of the RANK-RANKL-OPG axis in skeletal muscle. Evidence suggests RANKL inhibition benefits skeletal muscle function, mass, fibre-type switching, calcium homeostasis and reduces fall incidence. However, there still exists ambiguity regarding the exact mechanistic actions and subsequent functional improvements. Other potential RANK-RANKL-OPG extra-osseous roles include regulation of neural-inflammation and glucose metabolism. Growing evidence suggests the RANK-RANKL-OPG axis may play a regulatory role in extra-osseous tissues, especially in skeletal muscle. Targeting RANKL may be a novel therapy in ameliorating loss of muscle mass and function. More research is warranted to determine the causality of the RANK-RANKL-OPG axis in extra-osseous tissues, especially those affected by aging.

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RANK-RANKL-OPG 轴在骨外的作用，重点关注骨骼肌。

综述的目的：本综述旨在整合最近关于RANK-RANKL-OPG轴在骨外（主要是在骨骼肌内）作用的观察结果：临床前研究发现，RANK-RANKL-OPG 轴在骨骼肌中发挥着潜在的作用。有证据表明，抑制 RANKL 有益于骨骼肌功能、质量、纤维类型转换、钙稳态和降低跌倒发生率。然而，在确切的机理作用和随后的功能改善方面仍存在模糊之处。其他潜在的 RANK-RANKL-OPG 骨外作用包括调节神经炎症和葡萄糖代谢。越来越多的证据表明，RANK-RANKL-OPG 轴可能在骨外组织中发挥调节作用，尤其是在骨骼肌中。以 RANKL 为靶点可能是一种改善肌肉质量和功能丧失的新型疗法。要确定 RANK-RANKL-OPG 轴在骨外组织（尤其是受衰老影响的组织）中的因果关系，还需要进行更多的研究。

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来源期刊

Current Osteoporosis Reports ENDOCRINOLOGY & METABOLISM-

CiteScore

8.40

自引率

2.30%

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期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of osteoporosis. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as current and future therapeutics, epidemiology and pathophysiology, and evaluation and management. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.

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