Physical stimuli-responsive polymeric patches for healthcare

IF 18 1区医学 Q1 ENGINEERING, BIOMEDICAL Bioactive Materials Pub Date : 2024-09-28 DOI:10.1016/j.bioactmat.2024.08.025

Yifan Cheng , Yuan Lu

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Abstract

Many chronic diseases have become severe public health problems with the development of society. A safe and efficient healthcare method is to utilize physical stimulus-responsive polymer patches, which may respond to physical stimuli, including light, electric current, temperature, magnetic field, mechanical force, and ultrasound. Under certain physical stimuli, these patches have been widely used in therapy for diabetes, cancer, wounds, hair loss, obesity, and heart diseases since they could realize controllable treatment and reduce the risks of side effects. This review sketches the design principles of polymer patches, including composition, properties, and performances. Besides, control methods of using different kinds of physical stimuli were introduced. Then, the fabrication methods and characterization of patches were explored. Furthermore, recent applications of these patches in the biomedical field were demonstrated. Finally, we discussed the challenges and prospects for its clinical translation. We anticipate that physical stimulus-responsive polymer patches will open up new avenues for healthcare by acting as a platform with multiple functions.

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用于医疗保健的物理刺激响应式聚合物贴片

随着社会的发展，许多慢性疾病已成为严重的公共卫生问题。物理刺激响应型聚合物贴片是一种安全高效的医疗方法，它可以对光、电流、温度、磁场、机械力和超声波等物理刺激做出响应。在特定的物理刺激下，这些贴片可实现可控治疗并降低副作用风险，因此被广泛应用于糖尿病、癌症、伤口、脱发、肥胖症和心脏病的治疗。本综述概述了聚合物贴片的设计原理，包括组成、特性和性能。此外，还介绍了使用不同物理刺激的控制方法。然后，探讨了贴片的制造方法和表征。此外，还展示了这些贴片在生物医学领域的最新应用。最后，我们讨论了其临床应用所面临的挑战和前景。我们预计，物理刺激响应式聚合物贴片作为一种具有多种功能的平台，将为医疗保健开辟新的途径。

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来源期刊

Bioactive Materials Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

28.00

自引率

6.30%

发文量

436

审稿时长

20 days

期刊介绍： Bioactive Materials is a peer-reviewed research publication that focuses on advancements in bioactive materials. The journal accepts research papers, reviews, and rapid communications in the field of next-generation biomaterials that interact with cells, tissues, and organs in various living organisms. The primary goal of Bioactive Materials is to promote the science and engineering of biomaterials that exhibit adaptiveness to the biological environment. These materials are specifically designed to stimulate or direct appropriate cell and tissue responses or regulate interactions with microorganisms. The journal covers a wide range of bioactive materials, including those that are engineered or designed in terms of their physical form (e.g. particulate, fiber), topology (e.g. porosity, surface roughness), or dimensions (ranging from macro to nano-scales). Contributions are sought from the following categories of bioactive materials: Bioactive metals and alloys Bioactive inorganics: ceramics, glasses, and carbon-based materials Bioactive polymers and gels Bioactive materials derived from natural sources Bioactive composites These materials find applications in human and veterinary medicine, such as implants, tissue engineering scaffolds, cell/drug/gene carriers, as well as imaging and sensing devices.