Neurophysiological activity following gains and losses among young adults with non-suicidal self-injury: An ERP study

IF 3.7 2区医学 Q1 PSYCHIATRY Journal of psychiatric research Pub Date : 2024-09-24 DOI:10.1016/j.jpsychires.2024.09.029

Ciqing Bao , Qiaoyang Zhang , Chen He , Haowen Zou , Yi Xia , Rui Yan , Lingling Hua , Zhijian Yao , Qing Lu

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Abstract

Objective

Non-suicidal self-injury (NSSI) is an increasingly concerning issue that is linked to a range of mental health problems. However, little is known about the potential neurophysiological mechanisms underlying risk decision-making in Major depressive disorder (MDD) patients with NSSI—the present study aimed to fill this important literature gap.

Methods

A total of 81 MDD patients (with NSSI: n = 40, without NSSI: n = 41) and 44 matched healthy controls (HC) underwent a modified version of the Iowa Gambling Task (IGT) while an electroencephalogram was recorded. Feedback-related negativity (FRN) and P300 were examined during the feedback stage of the risky decision-making process.

Results

Behavioural findings revealed that individuals diagnosed with MDD displayed a greater tendency to make risky decisions compared to the control group. Furthermore, MDD patients with NSSI demonstrated a significantly more negative ΔFN (i.e., the difference in neural response to losses compared to gains) than those without NSSI. Further, NSSI patients showed a larger difference ΔFN (loss minus gain), which was associated with enhanced impulsivity.

Conclusions

Collectively, the findings suggest that there is an altered processing of risky decision-making in the electrophysiology of patients with MDD who engage in NSSI. The ΔFN may serve as a psychophysiological marker indicating risk for NSSI.

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非自杀性自伤的年轻成年人在获得和失去后的神经生理活动：ERP研究

目的非自杀性自伤（NSSI）是一个日益令人担忧的问题，它与一系列心理健康问题有关。本研究旨在填补这一重要的文献空白。方法：81 名重度抑郁障碍（MDD）患者（有 NSSI：40 人，无 NSSI：41 人）和 44 名匹配的健康对照（HC）接受了改良版的爱荷华赌博任务（IGT），同时记录脑电图。结果行为学研究结果显示，与对照组相比，被诊断为 MDD 的患者更倾向于做出风险决策。此外，与无 NSSI 患者相比，有 NSSI 的 MDD 患者表现出明显更消极的 ΔFN（即对损失与收益的神经反应差异）。此外，NSSI 患者表现出更大的ΔFN 差异（损失减去收益），这与冲动性增强有关。ΔFN可作为一种心理生理学标记，指示NSSI的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;