Modified Intravascular Stent for Microvascular Suture in a Rat Superficial Femoral Artery.

IF 1.4 4区医学 Q3 SURGERY Annals of Plastic Surgery Pub Date : 2024-09-19 DOI:10.1097/SAP.0000000000004098

Kosuke Maeda, Taku Suzuki, Yohei Masugi, Osahiko Tsuji, Takuji Iwamoto, Masaya Nakamura

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Abstract

Background: Intravascular stent (IVaS) is sometimes used for suturing small vessels, but removing the stent after suturing is difficult. To overcome this problem, we developed an IVaS that integrates a stent and a manipulating string. This study aimed to investigate the usefulness of the modified IVaS (M-IVaS) by comparing it with conventional sutures (CS) and conventional IVaS (C-IVaS).

Methods: Forty-five superficial femoral arteries from rats were resected and sutured. The rats were randomly divided into the following 3 groups: CS, M-IVaS, and C-IVaS, with 15 rats per group. Patency rate, operating time, and ultrasonographic blood flow dynamics were examined immediately after suturing. Patency tests, ultrasonographic evaluations, and histological investigations were performed 1 week (n = 5), 2 weeks (n = 5), and 6 weeks (n = 5) after surgery.

Results: The 3 groups showed vessel patency in all cases immediately after suturing and at 1 week, 2 weeks, and 6 weeks after surgery. The mean operative time was 22.6 minutes for the CS group, 21.5 minutes for the M-IVaS group, and 25.9 minutes for the C-IVaS group. There were no significant differences in peak flow velocity and stenosis rate among the 3 groups as evaluated by ultrasonography. Histopathological evaluation revealed a similar recovery process of endothelial cells and no damage to the vascular wall.

Conclusion: The surgical time using M-IVaS was significantly shorter compared to that using C-IVaS. The M-IVaS reduced the inconvenience of C-IVaS removal. M-IVaS showed the same effectiveness as did the CS in terms of patency rate, operating time, ultrasonographic blood flow dynamics, and histological evaluation. M-IVaS can be used in the field of microsurgery.

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用于大鼠股浅动脉微血管缝合的改良型血管内支架

背景：血管内支架（IVaS）有时用于缝合小血管，但缝合后取出支架很困难。为了克服这一问题，我们开发了一种将支架和操纵绳整合在一起的 IVaS。本研究旨在通过与传统缝合器（CS）和传统IVAS（C-IVAS）的比较，研究改良型IVAS（M-IVAS）的实用性：方法：切除并缝合 45 只大鼠的股浅动脉。大鼠随机分为以下 3 组：CS、M-IVaS 和 C-IVaS，每组 15 只。缝合后立即检查通畅率、手术时间和超声血流动力学。术后 1 周（5 只）、2 周（5 只）和 6 周（5 只）分别进行了通畅测试、超声波评估和组织学检查：3 组病例在缝合后立即以及术后 1 周、2 周和 6 周均显示血管通畅。CS 组的平均手术时间为 22.6 分钟，M-IVaS 组为 21.5 分钟，C-IVaS 组为 25.9 分钟。通过超声波检查评估，三组的峰值流速和狭窄率无明显差异。组织病理学评估显示，内皮细胞的恢复过程相似，血管壁无损伤：结论：使用 M-IVaS 的手术时间明显短于使用 C-IVaS 的手术时间。结论：使用 M-IVaS 的手术时间明显短于使用 C-IVaS 的手术时间。在通畅率、手术时间、超声血流动力学和组织学评估方面，M-IVaS显示出与CS相同的有效性。M-IVaS 可用于显微外科领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Plastic Surgery 医学-外科

CiteScore

2.70

自引率

13.30%

发文量

584

审稿时长

6 months

期刊介绍： The only independent journal devoted to general plastic and reconstructive surgery, Annals of Plastic Surgery serves as a forum for current scientific and clinical advances in the field and a sounding board for ideas and perspectives on its future. The journal publishes peer-reviewed original articles, brief communications, case reports, and notes in all areas of interest to the practicing plastic surgeon. There are also historical and current reviews, descriptions of surgical technique, and lively editorials and letters to the editor.