Maximum standardized uptake value-to-tumor size ratio in fluorodeoxyglucose F18 positron emission tomography/computed tomography: a simple prognostic parameter for non-small cell lung cancer.

Abstract

Purpose: By correcting the effect of tumor size on metabolic activity, the maximum standardized uptake value-to-tumor size (SUV_max:tumor size) ratio on fluorodeoxyglucose F18 positron emission tomography (¹⁸F-FDG PET)/computed tomography (CT) scans can be a prognostic parameter of non-small cell lung cancer (NSCLC). The current study evaluates the prognostic value of SUV_max:tumor size ratio on pretreatment ¹⁸F-FDG PET/CT scans in patients with NSCLC. Furthermore, the SUV_max:tumor size ratio is compared with other established PET parameters.

Methods: This study included 108 patients with NSCLC who underwent pretreatment ¹⁸F-FDG PET/CT scans and curative lung surgery. The associations between the SUV_max:tumor size ratio and other conventional PET parameters were investigated. The recurrence-free survival according to the SUV_max:tumor size ratio was also analyzed. In addition, the SUV_max:tumor size ratio was compared according to postoperative pathologic findings.

Results: In total, 72 (66.7%) of the 108 participants presented with adenocarcinoma (ADC). Nineteen (17.6%) patients experienced recurrence during a median follow-up period of 32.3 months. The median SUV max:tumor size ratio was 2.37 (1.23 for ADCs and 3.90 for other histologic types). The SUV_max:tumor size ratio was associated with SUV_max and mean SUV, as well as metabolic tumor volume and total lesion glycolysis. Patients with an SUV_max:tumor size ratio higher than the median had a worse recurrence outcome than those with an SUV_max:tumor size ratio lower than the median. Participants with ADC who presented with lymphovascular invasion had a higher SUV_max:tumor size ratio than those without. The presence of lymph node metastasis and advanced histologic grade were associated with a high SUV_max:tumor size ratio in patients with ADC.

Conclusion: The SUV_max:tumor size ratio on pretreatment ¹⁸F-FDG PET/CT scans was associated with aggressive tumor behavior and poor outcome in NSCLCs, particularly ADC.

Clinical significance: The SUV_max:tumor size ratio on pretreatment ¹⁸F-FDG PET/CT scans has a prognostic value in patients with NSCLCs, especially ADC.