Mendelian Randomization Studies in Atherosclerotic Cardiovascular Diseases.

Q2 Medicine Journal of Lipid and Atherosclerosis Pub Date : 2024-09-01 Epub Date: 2024-05-27 DOI:10.12997/jla.2024.13.3.280
Dai Sik Ko, Yun Hak Kim
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Abstract

This review aimed to highlight the pivotal role of Mendelian randomization (MR) in advancing atherosclerotic cardiovascular disease (ASCVD) research-a field often hindered by the complexities and limitations of traditional studies. MR, which uses genetic variants as instrumental variables, provides a robust mechanism for inferring causality, offering insights untainted by the confounding factors and biases often prevalent in observational and randomized controlled trials. We explored the significant contributions of MR for elucidating the causal relationship between low-density lipoprotein cholesterol and ASCVD, and analyzed its assumptions and methodological nuances. We discussed issues surrounding instrumental variable selection, pleiotropy, and ethical considerations, in an effort to offer a balanced and insightful analysis. We highlighted the promising integration of MR with emerging technologies and global data sharing, as well as its potential to drive personalized medicine. This review provided a concise yet comprehensive journey into MR's transformative impact on ASCVD research, offering a blend of current insights and challenges, in addition to future prospects. We aimed to serve a valuable resource for those seeking to navigate the intricate pathways of causality and intervention in ASCVD, to aid the development of enhanced understanding and targeted treatment strategies in the future.

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动脉粥样硬化性心血管疾病的孟德尔随机化研究。
这篇综述旨在强调孟德尔随机化(MR)在推动动脉粥样硬化性心血管疾病(ASCVD)研究方面的关键作用--这一领域往往受到传统研究的复杂性和局限性的阻碍。遗传因子随机化将遗传变异作为工具变量,为推断因果关系提供了一种稳健的机制,使研究不受观察性试验和随机对照试验中常见的混杂因素和偏差的影响。我们探讨了 MR 对阐明低密度脂蛋白胆固醇与 ASCVD 之间因果关系的重大贡献,并分析了其假设条件和方法上的细微差别。我们讨论了与工具变量选择、多效性和伦理考虑有关的问题,力求提供平衡而有见地的分析。我们强调了磁共振与新兴技术和全球数据共享的整合前景,以及其推动个性化医疗的潜力。这篇综述简明而全面地介绍了磁共振对急性心血管病研究的变革性影响,提供了当前的见解和挑战,以及未来的前景。我们的目标是为那些寻求探索 ASCVD 病因和干预的复杂路径的人提供宝贵的资源,帮助他们加深理解并在未来制定有针对性的治疗策略。
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来源期刊
Journal of Lipid and Atherosclerosis
Journal of Lipid and Atherosclerosis Medicine-Internal Medicine
CiteScore
6.90
自引率
0.00%
发文量
26
审稿时长
12 weeks
期刊最新文献
Comparison of Multiple Equations for Low-Density Lipoprotein Cholesterol Calculation Against the Direct Homogeneous Method. Emerging Circulating Biomarkers for Enhanced Cardiovascular Risk Prediction. Extracellular Vesicles as Mediators in Atherosclerotic Cardiovascular Disease. Mendelian Randomization Studies in Atherosclerotic Cardiovascular Diseases. Nrf2 Connects Cellular Autophagy and Vascular Senescence in Atherosclerosis: A Mini-Review.
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