Evaluation of brain metabolism using F18-FDG PET/CT imaging in patients diagnosed with lung cancer.

IF 1.3 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Nuclear Medicine Communications Pub Date : 2024-10-02 DOI:10.1097/MNM.0000000000001911

Ahmet E Şen, Buğra Kaya, Hakan Ş Bozcuk, Özlem Şahin, Mehmet Uyar, Mehmet Artaç, Mustafa Erol

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Abstract

Objectives: Brain imaging of regional metabolic changes in cancer patients can provide insights into cancer biology. We aimed to detect regional metabolic changes in the brains of untreated lung cancer patients without brain metastases using 2-deoxy-2-[18F]fluoroglucose PET/computed tomography.

Methods: The study included 44 lung cancer patients and 17 non-cancer patients as controls. Standardized uptake value (SUV) mean values of 68 different brain regions were recorded, and their ratios to whole brain and brainstem SUVmean were calculated.

Results: Comparisons between the groups showed significant reductions in the frontal lobe, inferior temporal gyrus, and right cingulate and paracingulate gyrus ratios in the patient group. Conversely, the right nucleus caudatus and right pallidum ratios were elevated. Correlation analysis with total lesion glycolysis (TLG) revealed positive correlations in the basal ganglia, right insula, amygdala, and right hippocampus ratios. Negative correlations were observed in the left frontal lobe and some temporal and parietal regions.

Conclusions: While most brain regions showed reduced metabolism, potentially due to tumor-brain glucose competition, others were preserved or positively correlated with TLG, suggesting a link to poor prognosis. The reduced metabolism in the frontal lobe might be associated with depression and cognitive decline in cancer patients.

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利用 F18-FDG PET/CT 成像评估肺癌患者的脑代谢。

目的：癌症患者脑部区域代谢变化的成像可为癌症生物学提供洞察力。我们的目的是利用 2-deoxy-2-[18F]fluoroglucose PET/计算机断层扫描检测未经治疗但无脑转移的肺癌患者脑部的区域代谢变化：研究包括 44 名肺癌患者和 17 名非癌症患者作为对照。记录了 68 个不同脑区的标准化摄取值（SUV）平均值，并计算了它们与全脑和脑干 SUV 平均值的比率：结果：组间比较显示，患者组的额叶、颞下回、右扣带回和旁扣带回比率显著降低。相反，右侧尾状核和右侧苍白球比率则升高。与总病变糖酵解（TLG）的相关性分析显示，基底节、右侧岛叶、杏仁核和右侧海马比率呈正相关。左侧额叶和一些颞叶及顶叶区域则呈负相关：结论：虽然大多数脑区的新陈代谢降低，这可能是由于肿瘤-脑葡萄糖竞争造成的，但其他脑区的新陈代谢保持不变，或与TLG呈正相关，这表明与不良预后有关。额叶新陈代谢的降低可能与癌症患者的抑郁和认知能力下降有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nuclear Medicine Communications 医学-核医学

CiteScore

2.20

自引率

6.70%

发文量

212

审稿时长

3-8 weeks

期刊介绍： Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.