Risk Factors for PVC Induced Cardiomyopathy and Post-Ablation Left Ventricular Systolic Dysfunction Reversibility: A Systematic Review and Meta-Analysis of Observational Studies.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-09-11 eCollection Date: 2024-09-01 DOI:10.31083/j.rcm2509327

Dongsheng Zhao, Qiushi Chen, Zhongyin Zhou, Pengcheng Zhao, Jianzhou Shi, Jun Yin, Qing Zhang, Fengxiang Zhang

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Abstract

Background: Premature ventricular complex (PVC) induced cardiomyopathy (PVC-CMP) and exacerbated left ventricular systolic dysfunction (LVSD) are common in clinical scenarios. However, their precise risk factors are currently unclear.

Methods: We performed a systematic review of PubMed, EMBASE, Web of Science, and Chinese-based literature database (CBM) to identify observational studies describing the factors associated with PVC-CMP and post-ablation LVSD reversibility. A total of 25 and 12 studies, involving 4863 and 884 subjects, respectively, were eligible. We calculated pooled multifactorial odds ratios (OR) and 95% confidence intervals (CI) for each parameter using random-effects and fixed-effects models.

Results: The results showed that 3 independent risk factors were associated with PVC-CMP: being asymptomatic (OR and 95% CI: 3.04 [2.13, 4.34]), interpolation (OR and 95% CI: 2.47 [1.25, 4.92]), and epicardial origin (epi-origin) (OR and 95% CI: 3.04 [2.13, 4.34]). Additionally, 2 factors were significantly correlated with post-ablation LVSD reversibility: sinus QRS wave duration (QRSd) (OR and 95% CI: 0.95 [0.93, 0.97]) and PVC burden (OR and 95% CI: 1.09 [0.97, 1.23]).

Conclusions: the relatively consistent independent risk factors for PVC-CMP and post-ablation LVSD reversibility are asymptomatic status, interpolation, epicardial origin, PVC burden, and sinus QRS duration, respectively.

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聚氯乙烯诱发心肌病的风险因素与消融后左室收缩功能障碍的可逆性：观察性研究的系统回顾和元分析》。

背景：室性早搏（PVC）诱发心肌病（PVC-CMP）和左室收缩功能障碍（LVSD）恶化在临床上很常见。然而，其确切的风险因素目前尚不清楚：我们对 PubMed、EMBASE、Web of Science 和中文文献数据库（CBM）进行了系统性回顾，以确定描述 PVC-CMP 和消融术后 LVSD 可逆性相关因素的观察性研究。符合条件的研究分别有25项和12项，分别涉及4863名和884名受试者。我们使用随机效应模型和固定效应模型计算了每个参数的多因素集合几率比（OR）和95%置信区间（CI）：结果显示，3个独立的风险因素与PVC-CMP相关：无症状（OR和95% CI：3.04 [2.13，4.34]）、插值（OR和95% CI：2.47 [1.25，4.92]）和心外膜起源（epi-origin）（OR和95% CI：3.04 [2.13，4.34]）。结论：PVC-CMP 和消融术后 LVSD 可逆性的相对一致的独立危险因素分别是无症状状态、内插、心外膜起源、PVC 负荷和窦性 QRS 波持续时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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