Angelicae dahuricae radix alleviates simulated microgravity induced bone loss by promoting osteoblast differentiation.

IF 4.4 1区物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES npj Microgravity Pub Date : 2024-10-01 DOI:10.1038/s41526-024-00433-0

Xuechao Liang, Shanfeng Jiang, Peihong Su, Chong Yin, Wei Jiang, Junhong Gao, Zhiyong Liu, Yuhang Li, Weisi Wang, Airong Qian, Ye Tian

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Abstract

Bone loss caused by long-duration spaceflight seriously affects the skeletal health of astronauts. There are many shortcomings in currently available treatments for weightlessness-induced bone loss. The aim of this study was to evaluate the preventive effect of Angelica dahuricae Radix (AR) on simulated microgravity-induced bone loss. Here, we established a hind limb unloading (HLU) mouse model and treated HLU mice with AR (2 g/kg) for 4 weeks. Results indicated that AR significantly inhibited simulated microgravity-induced bone loss. In addition, the components in AR were analyzed using UPLC-MS/MS; results showed that a total of 224 compounds were detected in AR, which mainly contained 7 classes of components. Moreover, the network pharmacological predictions suggested that active ingredients of AR might act on PTGS2 to prevent bone loss. These results elucidate the efficacy of AR in preventing microgravity-induced bone loss and its potential for use in protecting the bone health of astronauts.

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白芷通过促进成骨细胞分化缓解模拟微重力诱导的骨质流失

长期太空飞行造成的骨质流失严重影响宇航员的骨骼健康。目前针对失重引起的骨质流失的治疗方法存在许多缺陷。本研究旨在评估白芷（Angelica dahuricae Radix，AR）对模拟微重力诱发骨质流失的预防作用。在此，我们建立了一个后肢卸载（HLU）小鼠模型，并用白芷（2 克/千克）治疗 HLU 小鼠 4 周。结果表明，AR 能明显抑制模拟微重力诱导的骨质流失。此外，还利用UPLC-MS/MS分析了AR中的成分，结果显示AR中共检测到224种化合物，主要包含7类成分。此外，网络药理学预测表明，AR 的有效成分可能会作用于 PTGS2，从而防止骨质流失。这些结果阐明了 AR 在预防微重力诱导的骨质流失方面的功效，以及其在保护宇航员骨骼健康方面的应用潜力。

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来源期刊

npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)

CiteScore

7.30

自引率

7.80%

发文量

审稿时长

9 weeks

期刊介绍： A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.