Modeling of Parkinson's Disease in Different Models.

Iqra Subhan, Yasir Hasan Siddique
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Abstract

Parkinson's Disease (PD) is a progressive disorder worldwide and its etiology remains unidentified. Over the last few decades, animal models of PD have been extensively utilized to explore the development and mechanisms of this neurodegenerative condition. Toxic and transgenic animal models for PD possess unique characteristics and constraints, necessitating careful consideration when selecting the appropriate model for research purposes. Animal models have played a significant role in uncovering the causes and development of PD, including its cellular and molecular processes. These models suggest that the disorder arises from intricate interplays between genetic predispositions and environmental influences. Every model possesses its unique set of strengths and weaknesses. This review provides a critical examination of animal models for PD and compares them with the features observed in the human manifestation of the disease.

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在不同模型中模拟帕金森病
帕金森病(Parkinson's Disease,PD)是一种全球性进展性疾病,其病因至今仍未确定。在过去几十年中,帕金森病动物模型被广泛用于探索这种神经退行性疾病的发展和机制。治疗帕金森病的毒性和转基因动物模型具有独特的特征和限制,因此在为研究目的选择合适的模型时必须慎重考虑。动物模型在揭示帕金森病的病因和发展过程(包括其细胞和分子过程)方面发挥了重要作用。这些模型表明,这种疾病是由遗传倾向和环境影响之间错综复杂的相互作用引起的。每种模型都有其独特的优缺点。本综述将对帕金森氏症的动物模型进行批判性研究,并将它们与人类表现出的帕金森氏症特征进行比较。
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