{"title":"Piecing together the intricate puzzle of organ recovery in AL amyloidosis.","authors":"Mario Nuvolone, Giovanni Palladini","doi":"10.1111/bjh.19810","DOIUrl":null,"url":null,"abstract":"<p><p>In AL amyloidosis, the factors hindering organ recovery despite deep haematological responses to anti-clonal therapy remain elusive. The study by Staron and colleagues identifies tissue-specific factors influencing the lack of organ response, including host-related characteristics, the properties of the amyloidogenic precursor, the extent of organ compromise at diagnosis and the dynamics and depth of haematological response. While this study begins to unravel the complex mechanisms underlying organ recovery in AL amyloidosis, it also raises critical questions that warrant further investigation through future collaborative research. Commentary on: Staron et al. Factors impeding organ recovery despite a deep haematological response in patients with systemic AL amyloidosis. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19766.</p>","PeriodicalId":135,"journal":{"name":"British Journal of Haematology","volume":null,"pages":null},"PeriodicalIF":5.1000,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"British Journal of Haematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/bjh.19810","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In AL amyloidosis, the factors hindering organ recovery despite deep haematological responses to anti-clonal therapy remain elusive. The study by Staron and colleagues identifies tissue-specific factors influencing the lack of organ response, including host-related characteristics, the properties of the amyloidogenic precursor, the extent of organ compromise at diagnosis and the dynamics and depth of haematological response. While this study begins to unravel the complex mechanisms underlying organ recovery in AL amyloidosis, it also raises critical questions that warrant further investigation through future collaborative research. Commentary on: Staron et al. Factors impeding organ recovery despite a deep haematological response in patients with systemic AL amyloidosis. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19766.
在AL淀粉样变性病中,尽管抗克隆治疗产生了深层血液学反应,但阻碍器官恢复的因素仍然难以捉摸。斯塔隆及其同事的研究确定了影响器官缺乏反应的组织特异性因素,包括宿主相关特征、淀粉样蛋白前体的特性、诊断时器官受损的程度以及血液学反应的动态和深度。这项研究开始揭示AL淀粉样变性器官恢复的复杂机制,同时也提出了一些关键问题,值得通过未来的合作研究进一步探讨。相关评论尽管系统性 AL 淀粉样变性患者有深度血液学反应,但阻碍器官恢复的因素。Doi: 10.1111/bjh.19766.
期刊介绍:
The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.