Frailty and health-related life quality in long-term follow up of intensive care patients above 65 years old: Protocol for a Norwegian prospective, observational multicenter study.

IF 1.9 4区医学 Q2 ANESTHESIOLOGY Acta Anaesthesiologica Scandinavica Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI:10.1111/aas.14532

B A Kroken, D Bergum, K S Berg, M Espinasse, O K Fossum, A M Garratt, Pal Klepstad, Reidar Kvåle, B Strand, Hans Kristian Flaatten, Shirin K Frisvold

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Abstract

Background: Frailty is strongly correlated with mortality in intensive care unit patients, yet routine screening among intensive care patients is rarely performed. The aim of this study is to assess frailty and health-related quality of life (HRQoL) in patients before intensive care admission and to compare this with outcomes after 3 and 12-months. The Clinical Frailty Scale and EQ-5D-5L will be used to assess frailty and HRQoL, respectively.

Methods: This is an ongoing, prospective observational study including patients from five Norwegian ICU's. Inclusion criteria are patients aged ≥65 years requiring invasive mechanical ventilation for ≥24 h. The Clinical Frailty Scale and EQ-5D-5L are administered at baseline (before critical illness) and at 3- and 12-months post-inclusion. Additional data collected includes patient characteristics, ICU treatment details, illness severity and mortality. The EQ-5D-5L will be compared to Norwegian population norms and assessed for measurement properties.

Results: Inclusion started July 2022 and will be stopped at 350 patients. The study will be completed in 2025.

Conclusion: The study will assess the feasibility and measurement properties of the Clinical Frailty Scale and EQ-5D-5L in ICU survivors by telephone at long-term follow-up study and will give additional information on the frailty and HRQoL of intensive care survivors.

Clinical trial registration: The study is registered in ClinicalTrials.gov NCT06012942. Protocol version 2.7.1, 19.05.2023.

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对 65 岁以上重症监护患者进行长期随访，了解他们的虚弱程度和健康相关生活质量：挪威前瞻性多中心观察研究方案。

背景：虚弱与重症监护室患者的死亡率密切相关，但很少对重症监护患者进行常规筛查。本研究旨在评估重症监护患者入院前的虚弱程度和与健康相关的生活质量（HRQoL），并将其与入院 3 个月和 12 个月后的结果进行比较。临床虚弱量表和 EQ-5D-5L 将分别用于评估虚弱程度和 HRQoL：这是一项正在进行的前瞻性观察研究，包括来自挪威五所重症监护病房的患者。纳入标准为年龄≥65岁、需要有创机械通气≥24小时的患者。在基线（危重病前）、纳入后3个月和12个月时使用临床虚弱量表和EQ-5D-5L。收集的其他数据包括患者特征、重症监护室治疗详情、病情严重程度和死亡率。EQ-5D-5L将与挪威人口标准进行比较，并对测量特性进行评估：研究结果：研究从 2022 年 7 月开始，到 350 名患者时结束。研究将于 2025 年结束：该研究将在长期随访研究中通过电话评估临床虚弱量表和EQ-5D-5L在重症监护室幸存者中的可行性和测量特性，并将提供有关重症监护室幸存者虚弱和HRQoL的更多信息：该研究已在 ClinicalTrials.gov NCT06012942 上注册。协议版本 2.7.1，2023 年 5 月 19 日。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Anaesthesiologica Scandinavica 医学-麻醉学

CiteScore

4.30

自引率

9.50%

发文量

157

审稿时长

3-8 weeks

期刊介绍： Acta Anaesthesiologica Scandinavica publishes papers on original work in the fields of anaesthesiology, intensive care, pain, emergency medicine, and subjects related to their basic sciences, on condition that they are contributed exclusively to this Journal. Case reports and short communications may be considered for publication if of particular interest; also letters to the Editor, especially if related to already published material. The editorial board is free to discuss the publication of reviews on current topics, the choice of which, however, is the prerogative of the board. Every effort will be made by the Editors and selected experts to expedite a critical review of manuscripts in order to ensure rapid publication of papers of a high scientific standard.