Bridging brain insulin resistance to Alzheimer’s pathogenesis

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI:10.1016/j.tibs.2024.09.004

Wenqiang Chen , Valdemar Brimnes Ingemann Johansen , Cristina Legido-Quigley

引用次数: 0

Abstract

Emerging evidence links type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD), with brain insulin resistance (BIR) as a key factor. In a recent study, Lanzillotta et al. reveal that reduced biliverdin reductase-A (BVR-A) impairs glycogen synthase kinase 3β (GSK3β) phosphorylation, causing mitochondrial dysfunction and exacerbating brain insulin resistance in the progression of both T2DM and AD.

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将大脑胰岛素抵抗与阿尔茨海默氏症发病机制联系起来。

越来越多的证据表明，2 型糖尿病（T2DM）和阿尔茨海默病（AD）之间存在联系，而脑胰岛素抵抗（BIR）是其中的一个关键因素。在最近的一项研究中，Lanzillotta 等人发现，胆绿素还原酶-A（BVR-A）的减少会损害糖原合成酶激酶 3β （GSK3β）的磷酸化，导致线粒体功能障碍，并在 T2DM 和 AD 的进展过程中加剧脑胰岛素抵抗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

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