Spatial Transcriptomics of the Respiratory System.

IF 15.7 1区 医学 Q1 PHYSIOLOGY Annual review of physiology Pub Date : 2024-10-01 DOI:10.1146/annurev-physiol-022724-105144
Stathis Megas, Anna Wilbrey-Clark, Aidan Maartens, Sarah A Teichmann, Kerstin B Meyer
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Abstract

Over the last decade, single-cell genomics has revealed remarkable heterogeneity and plasticity of cell types in the lungs and airways. The challenge now is to understand how these cell types interact in three-dimensional space to perform lung functions, facilitating airflow and gas exchange while simultaneously providing barrier function to avoid infection. An explosion in novel spatially resolved gene expression technologies, coupled with computational tools that harness machine learning and deep learning, now promise to address this challenge. Here, we review the most commonly used spatial analysis workflows, highlighting their advantages and limitations, and outline recent developments in machine learning and artificial intelligence that will augment how we interpret spatial data. Together these technologies have the potential to transform our understanding of the respiratory system in health and disease, and we showcase studies in lung development, COVID-19, lung cancer, and fibrosis where spatially resolved transcriptomics is already providing novel insights.

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呼吸系统的空间转录组学。
过去十年间,单细胞基因组学揭示了肺和气道中细胞类型的显著异质性和可塑性。现在的挑战是了解这些细胞类型如何在三维空间中相互作用,以发挥肺功能,促进气流和气体交换,同时提供屏障功能以避免感染。新颖的空间分辨基因表达技术层出不穷,加上利用机器学习和深度学习的计算工具,现在有望解决这一难题。在此,我们回顾了最常用的空间分析工作流程,强调了它们的优势和局限性,并概述了机器学习和人工智能的最新发展,它们将增强我们解读空间数据的方式。我们将展示肺发育、COVID-19、肺癌和肺纤维化方面的研究,在这些研究中,空间解析转录组学已经提供了新的见解。
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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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