Evaluation of primary markers of inflammation and the systemic inflammation index in specific learning disabilities.

IF 1.9 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Biomarkers in medicine Pub Date : 2024-01-01 Epub Date: 2024-10-03 DOI:10.1080/17520363.2024.2404387

Pınar Aydoğan Avşar, Tayfun Kara, Orhan Kocaman, Merve Akkuş

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Abstract

Aim: Specific learning disorder (SLD) is a term that refers to reading, writing and arithmetic difficulties. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic inflammation index (SII) are affordable and accessible inflammatory biomarkers. This research aims to evaluate the relationship between NLR, PLR, SII and SLD to determine whether inflammation contributes to pathogenesis.Methods: This study included 90 SLD-diagnosed patients and 90 age-, sex- and ethnicity-matched healthy controls. Blood cell counts and NLR, PLR and SII values were obtained from medical records and compared between the two groups.Results: The NLR, PLR and SII were significantly higher (p = 0.029, p = 0.033 and p = 0.018 respectively) and lymphocyte counts were significantly lower (p = 0.041) in the SLD group. WISC-R total scores decreased with age in the SLD group (-1.988 coefficient, Beta = -0.247 ß, p = 0.041). Multivariate logistic regression analysis revealed that the SII was the only parameter independently associated with the diagnosis of SLD (Beta = 0.003, p = 0.023).Conclusion: Inflammation might play a role in SLD etiopathogenesis. NLR, PLR and SII may be potential biomarkers for SLD in children. Further research may lead to early diagnosis and additional anti-inflammatory pharmacological therapies for SLDs.

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评估特殊学习障碍的主要炎症指标和全身炎症指数。

目的：特殊学习障碍（SLD）是指阅读、写作和算术困难。中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）和全身炎症指数（SII）是负担得起且容易获得的炎症生物标志物。本研究旨在评估 NLR、PLR、SII 和 SLD 之间的关系，以确定炎症是否导致发病：本研究包括 90 名确诊为 SLD 的患者和 90 名年龄、性别和种族匹配的健康对照者。从病历中获取血细胞计数和 NLR、PLR 和 SII 值，并对两组进行比较：结果：SLD 组的 NLR、PLR 和 SII 值明显较高（分别为 p = 0.029、p = 0.033 和 p = 0.018），而淋巴细胞计数则明显较低（p = 0.041）。SLD组的WISC-R总分随年龄增长而降低（系数-1.988，Beta = -0.247 ß，p = 0.041）。多变量逻辑回归分析显示，SII是唯一与SLD诊断独立相关的参数（Beta = 0.003，p = 0.023）：炎症可能在SLD的发病机制中起一定作用。NLR、PLR和SII可能是儿童SLD的潜在生物标志物。进一步的研究可能会为 SLD 带来早期诊断和更多的抗炎药物疗法。

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来源期刊

Biomarkers in medicine 医学-医学：研究与实验

CiteScore

3.80

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory. Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice. As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications. Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest. Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.