Diagnostic value of Midkine and AFP in the detection of hepatocellular carcinoma: A systematic review and meta-analysis.

Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI:10.22088/cjim.15.4.559

Masrul Lubis, Darmadi Darmadi, Sem Samuel Surja, Cennikon Pakpahan

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Abstract

Background: Hepatocellular carcinoma (HCC) posed significant health problems and deaths. There are various challenges in the management of HCC, including the late detection or diagnosis. The ongoing diagnostic method in HCC also hinders the detection on the early stages of the disease, thus biomarkers need to be explored further for HCC detection. Serum alpha fetoprotein (AFP) and Midkine (MDK) are two proteins which might be the biomarker of choice in the detection of HCC. This meta-analysis aims to analyze the accuracy of Midkine and AFP in the detection of HCC.

Methods: The systematic review and meta-analysis was conducted by adhering to the Preferred Reporting System for Systematic Review and Meta-Analysis (PRISMA) guidelines. We conduct literature screening and selection followed by quality assessment from various databases such as PubMed, MEDLINE, SpringerLink, ProQuest, EBSCOhost, Cochrane, and EMBASE. The included studies were then extracted and analyzed cumulatively using MedCalc and MetaDTA with forest plot and ROC curve as outcome.

Results: 12 studies were included in this study. The AFP biomarker yields sensitivity value of 62.5% (97.5% CI 0.442 - 0.778) and specificity value of 95% (97.5% CI 0.842 - 0.986), while the Midkine biomarker denotes sensitivity value of 91.6% (97.5% CI 0.83 - 0.961) and specificity value of 82.2% (97.5% CI 0.83 - 0.96).

Conclusions: Both AFP and MDK are proven to be a good diagnostic tool or biomarker in the detection of HCC. The use of both in combination should provide high quality diagnostic marker for HCC suspected patients. Further studies on this should be conducted.

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Midkine 和 AFP 在检测肝细胞癌中的诊断价值：系统回顾和荟萃分析。

背景：肝细胞癌（HCC）造成了严重的健康问题和死亡。HCC 的治疗面临着各种挑战，包括检测或诊断过晚。目前对 HCC 的诊断方法也阻碍了对疾病早期阶段的检测，因此需要进一步探索用于检测 HCC 的生物标志物。血清甲胎蛋白（AFP）和Midkine（MDK）这两种蛋白可能是检测HCC的首选生物标志物。本荟萃分析旨在分析 Midkine 和 AFP 检测 HCC 的准确性：系统综述和荟萃分析遵循系统综述和荟萃分析首选报告系统（PRISMA）指南进行。我们从 PubMed、MEDLINE、SpringerLink、ProQuest、EBSCOhost、Cochrane 和 EMBASE 等多个数据库中进行文献筛选和质量评估。然后使用 MedCalc 和 MetaDTA 对纳入的研究进行提取和累积分析，并以森林图和 ROC 曲线作为分析结果：本研究共纳入 12 项研究。AFP生物标志物的敏感性为62.5%（97.5% CI 0.442 - 0.778），特异性为95%（97.5% CI 0.842 - 0.986），而Midkine生物标志物的敏感性为91.6%（97.5% CI 0.83 - 0.961），特异性为82.2%（97.5% CI 0.83 - 0.96）：AFP和MDK都被证明是检测HCC的良好诊断工具或生物标志物。将二者结合使用可为 HCC 疑似患者提供高质量的诊断标志物。应就此开展进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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