Quality of life and functional outcome of rectal cancer patients: A prospective cohort study

IF 2.9 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Colorectal Disease Pub Date : 2024-10-02 DOI:10.1111/codi.17181

Alexander J. Pennings, Geraldine R. Vink, Sander van Kuijk, Jarno Melenhorst, Geerard L. Beets, Anne M. May, Stephanie O. Breukink

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Abstract

Aim

In the last decade, the Netherlands has implemented various diagnostic and treatment strategies to enhance rectal cancer outcomes. This study, using data from the Prospective Dutch ColoRectal Cancer (PLCRC) cohort, investigates whether these multidisciplinary advancements have translated into improved health-related quality of life (HRQoL) and functional outcomes for the general Dutch rectal cancer population.

Methods

Patients with Stage I–III rectal cancer enrolled in the PLCRC cohort were included. HRQoL and functional outcomes were assessed 1 and 2 years after diagnosis using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), EORTC QLQ Colorectal Cancer 29 and the Low Anterior Resection Syndrome score. HRQoL and functional outcomes were compared based on year of diagnosis (2014–2019).

Results

A total of 1294 patients were included. Two years after diagnosis, patients diagnosed in 2019 (n = 392) had a clinically relevant higher score on physical (8.2, 95% CI 4.1–12.3), role (13.5, 95% CI 7.3–19.7) and social functioning (5.8, 95% CI 0.3–11.2) compared to those diagnosed in 2014 (n = 65). Additionally, patients diagnosed in 2019 experienced less fatigue 2 years after diagnosis compared to those diagnosed in 2014 (−8.6, 95% CI −14.1 to −3.0). The Low Anterior Resection Syndrome score showed no differences.

Conclusion

The findings of this study suggest that over the past decade rectal cancer patients in the Netherlands have witnessed improvements in HRQoL across various domains. Most probably, the improvement is due to a combination of implementation of population screening, a more restrictive neoadjuvant radiotherapy policy and advances in minimally invasive surgery and organ preserving treatment options.

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直肠癌患者的生活质量和功能预后：前瞻性队列研究

目的：在过去十年中，荷兰实施了各种诊断和治疗策略，以提高直肠癌的治疗效果。本研究利用前瞻性荷兰直肠癌队列（PLCRC）的数据，调查这些多学科进展是否改善了荷兰直肠癌患者的健康相关生活质量（HRQoL）和功能预后：方法：纳入 PLCRC 队列中的 I-III 期直肠癌患者。采用欧洲癌症研究和治疗组织生活质量问卷核心30（EORTC QLQ-C30）、EORTC QLQ结直肠癌29和低位前切除综合征评分对确诊后1年和2年的HRQoL和功能结果进行评估。根据诊断年份（2014-2019 年）对 HRQoL 和功能结果进行比较：结果：共纳入 1294 名患者。确诊两年后，与2014年确诊的患者（n = 65）相比，2019年确诊的患者（n = 392）在身体（8.2，95% CI 4.1-12.3）、角色（13.5，95% CI 7.3-19.7）和社会功能（5.8，95% CI 0.3-11.2）方面的临床相关性得分更高。此外，与2014年确诊的患者相比，2019年确诊的患者在确诊2年后的疲劳程度较低（-8.6，95% CI -14.1至-3.0）。低前切除综合征评分没有显示出差异：本研究结果表明，在过去十年中，荷兰的直肠癌患者在各方面的 HRQoL 都有所改善。这种改善很可能是由于实施了人群筛查、更严格的新辅助放疗政策以及微创手术和保留器官治疗方案的进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colorectal Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

11.80%

发文量

406

审稿时长

1.5 months

期刊介绍： Diseases of the colon and rectum are common and offer a number of exciting challenges. Clinical, diagnostic and basic science research is expanding rapidly. There is increasing demand from purchasers of health care and patients for clinicians to keep abreast of the latest research and developments, and to translate these into routine practice. Technological advances in diagnosis, surgical technique, new pharmaceuticals, molecular genetics and other basic sciences have transformed many aspects of how these diseases are managed. Such progress will accelerate. Colorectal Disease offers a real benefit to subscribers and authors. It is first and foremost a vehicle for publishing original research relating to the demanding, rapidly expanding field of colorectal diseases. Essential for surgeons, pathologists, oncologists, gastroenterologists and health professionals caring for patients with a disease of the lower GI tract, Colorectal Disease furthers education and inter-professional development by including regular review articles and discussions of current controversies. Note that the journal does not usually accept paediatric surgical papers.