Six new sesquineolignans from the stems of Akebia quinate and their diacylglycerol acyltransferase activity

IF 2.5 3区 医学 Q3 CHEMISTRY, MEDICINAL Fitoterapia Pub Date : 2024-09-30 DOI:10.1016/j.fitote.2024.106221
Wen-Hui Xu , Yi-Ran Jiang , Tian-Tian Bei , Ying-Xiao Xiao , Yuan Gao , Hao Xu , Xue-Feng Wu , Hyun-Sun Lee , Long Cui
{"title":"Six new sesquineolignans from the stems of Akebia quinate and their diacylglycerol acyltransferase activity","authors":"Wen-Hui Xu ,&nbsp;Yi-Ran Jiang ,&nbsp;Tian-Tian Bei ,&nbsp;Ying-Xiao Xiao ,&nbsp;Yuan Gao ,&nbsp;Hao Xu ,&nbsp;Xue-Feng Wu ,&nbsp;Hyun-Sun Lee ,&nbsp;Long Cui","doi":"10.1016/j.fitote.2024.106221","DOIUrl":null,"url":null,"abstract":"<div><div>Six new sesquineolignans (<strong>1–6</strong>), have been isolated and elucidated from the stems of <em>Akebia quinate</em> together with five known analogues (<strong>7–11</strong>). Their structures were elucidated on the basis of comprehensive analysis of UV, IR, NMR, HRESIMS and CD spectroscopy experiments. All the isolates were evaluated for <em>in vitro</em> inhibitory activity against DGAT1 and DGAT2. Among them, compounds <strong>1–11</strong> were found to exhibit selective inhibitory activity on DGAT1 with IC<sub>50</sub> values ranging from 60.4 ± 1.3 to 84.6 ± 1.3 μM. Besides, the potential binding sites of <strong>1</strong> were predicted by molecular docking.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106221"},"PeriodicalIF":2.5000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004040","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0

Abstract

Six new sesquineolignans (1–6), have been isolated and elucidated from the stems of Akebia quinate together with five known analogues (7–11). Their structures were elucidated on the basis of comprehensive analysis of UV, IR, NMR, HRESIMS and CD spectroscopy experiments. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 1–11 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 60.4 ± 1.3 to 84.6 ± 1.3 μM. Besides, the potential binding sites of 1 were predicted by molecular docking.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
琥珀酸赤萍茎中的六种新芝麻素及其二酰甘油酰基转移酶活性。
研究人员从喹乙酸鹰嘴豆(Akebia quinate)的茎中分离并阐明了六种新的芝麻木脂素(1-6)以及五种已知的类似物(7-11)。它们的结构是在紫外光谱、红外光谱、核磁共振、HRESIMS 和 CD 光谱实验综合分析的基础上阐明的。评估了所有分离物对 DGAT1 和 DGAT2 的体外抑制活性。其中,化合物 1-11 对 DGAT1 具有选择性抑制活性,其 IC50 值为 60.4 ± 1.3 至 84.6 ± 1.3 μM。此外,还通过分子对接预测了 1 的潜在结合位点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Fitoterapia
Fitoterapia 医学-药学
CiteScore
5.80
自引率
2.90%
发文量
198
审稿时长
1.5 months
期刊介绍: Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
期刊最新文献
Pharmacology, phytochemistry, and traditional uses of Huperzia serrata (Thunb. ex Murray) Trev. Ten limonoids and three protolimonoids from the Thai mangrove Xylocarpus moluccensis. Diterpenoids and lignans from the stems of Tripterygium wilfordii and their anti-inflammatory activities. Assessment of lapachol's anti-inflammatory effectiveness in mitigating sepsis-induced acute lung injury. Phytochemical characterization, toxicity and pharmacological profile of the central effects of the fixed fruit pulp oil of Mauritia flexuosa L.F. (buriti).
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1