Altered Brain Structure in Hemifacial Spasm Patients: A Multimodal Brain Structure Study.

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of General Medicine Pub Date : 2024-09-28 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S464660

Qingyang Yu, Yuanyuan Cui, Shuwen Dong, Yanqing Ma, Yi Xiao, Li Fan, Shiyuan Liu

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Abstract

Objective: Hemifacial spasm (HFS) is a clinical neurosurgical disease, which brain structural alterations caused by HFS remain a topic of debate. We evaluated changes in brain microstructure associated with HFS and observed their relevance to clinical characteristics.

Methods: We enrolled 72 participants. T1-weighted structural and diffusion tensor images were collected from all participants using 3.0T magnetic resonance equipment. Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) were used to identify changes in gray matter volume (GMV) and disruptions in white matter (WM) integrity. The severity of the spasms was graded using the Cohn scale.

Results: VBM analysis revealed that the GMV was significantly reduced in the left Thalamus and increased GMV in the right Cerebellum IV-V of the HFS group. TBSS analysis showed that FA in the left superior longitudinal fasciculus (SLF) of the HFS group was significantly increased. GMV in the thalamus showed a negative correlation with disease duration and Cohn grade, while FA in the left SLF had a positive correlation with both the disease duration and Cohn grade.

Conclusion: We identified regions with altered GMV in HFS patients. Additionally, we determined that FA in the left SLF might serve as a significant neural indicator of HFS.

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面肌痉挛患者大脑结构的改变：多模态脑结构研究

目的：面肌痉挛（HFS）是一种临床神经外科疾病，HFS引起的脑结构改变仍是一个争论不休的话题。我们评估了与 HFS 相关的脑微结构变化，并观察了其与临床特征的相关性：我们招募了 72 名参与者。我们使用 3.0T 磁共振设备采集了所有参与者的 T1 加权结构和弥散张量图像。基于体素的形态计量学（VBM）和基于束的空间统计学（TBSS）被用来识别灰质体积（GMV）的变化和白质（WM）完整性的破坏。痉挛的严重程度采用科恩量表分级：VBM分析显示，HFS组左侧丘脑的GMV明显减少，右侧小脑IV-V的GMV增加。TBSS分析显示，HFS组左侧上纵筋束（SLF）的FA明显增加。丘脑的GMV与病程和Cohn分级呈负相关，而左侧SLF的FA与病程和Cohn分级均呈正相关：结论：我们发现了 HFS 患者 GMV 发生变化的区域。此外，我们还发现左侧SLF的FA可能是HFS的一个重要神经指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.