When You Get to the Fork in the Road, Take It: The Challenges in Managing Patients With Advanced Prostate Cancer.

IF 4.7 3区 医学 Q1 ONCOLOGY JCO oncology practice Pub Date : 2024-10-01 DOI:10.1200/OP-24-00591
Paul Viscuse, William P Skelton, Michael M Devitt, Robert Dreicer
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Abstract

As is the case with most solid tumors, the heterogeneity of the disease biology of prostate cancer presents clinicians managing this disease with daily challenges. However, in contrast to other common cancers such as breast, lung, and colorectal cancers, there are unique challenges in prostate cancer management, including the variety of clinicians who manage aspects of the disease (urologists, medical oncologist, radiation oncologists) and the striking absence of prospective comparative data to inform the optimal sequence of systemic therapy in patients with metastatic castration-resistant disease. The purpose of this review is to attempt to assist practicing oncologists with sorting through the myriad of prostate cancer disease subsets and the challenges in making therapeutic decisions in multiple data-free zones given the absence of level 1 comparative clinical trials in the metastatic hormone-sensitive and castration-resistant states.

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当你走到岔路口时,请抓住它:管理晚期前列腺癌患者的挑战。
与大多数实体瘤一样,前列腺癌疾病生物学的异质性也给临床医生带来了日常的挑战。然而,与乳腺癌、肺癌和结肠直肠癌等其他常见癌症相比,前列腺癌的治疗面临着独特的挑战,包括管理该疾病的临床医生(泌尿科医生、肿瘤内科医生、肿瘤放射科医生)的多样性,以及前瞻性对比数据的严重缺乏,无法为转移性耐受性阉割疾病患者的最佳系统治疗顺序提供依据。本综述的目的是试图帮助执业肿瘤学家理清前列腺癌疾病的众多子集,以及在转移性激素敏感和阉割耐药状态下缺乏一级对比临床试验的情况下,在多个无数据区做出治疗决策所面临的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.40
自引率
7.50%
发文量
518
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