Sex Differences in Allergic Bronchopulmonary Aspergillosis and its Impact on Exacerbations.

IF 3.6 3区生物学 Q2 MYCOLOGY Mycopathologia Pub Date : 2024-10-03 DOI:10.1007/s11046-024-00893-8

Ritesh Agarwal, Valliappan Muthu, Inderpaul Singh Sehgal, Kuruswamy Thurai Prasad, Sahajal Dhooria, Mandeep Garg, Ashutosh N Aggarwal, Shivaprakash M Rudramurthy, Arunaloke Chakrabarti

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Abstract

The impact of sex on allergic bronchopulmonary aspergillosis (ABPA) outcomes remains uncertain. We retrospectively included ABPA subjects per the revised International Society for Human and Animal Mycology ABPA working group criteria over 13 years. We compared the clinical features, lung function, immunological tests, imaging, and ABPA exacerbation rates between men and women. Our primary objective was to assess whether women experience higher ABPA exacerbations than men. We included 731 ABPA subjects (mean age, 34.5 years; 49.5% women). Women with ABPA were older and had underlying asthma more frequently than men. There was no difference in lung function, immunological investigations, and imaging between men and women. ABPA exacerbations occurred in a slightly higher proportion of women than men (44.5% vs. 38.2%) but did not reach statistical significance (p = 0.09). We did not find a significant sex difference in ABPA exacerbation rates. Prospective studies should confirm our findings.

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过敏性支气管肺曲霉菌病的性别差异及其对病情恶化的影响

性别对过敏性支气管肺曲霉菌病（ABPA）结果的影响仍不确定。我们根据国际人类与动物真菌学会 ABPA 工作组修订后的标准，回顾性地纳入了 13 年来的 ABPA 受试者。我们比较了男性和女性的临床特征、肺功能、免疫学检测、影像学和 ABPA 恶化率。我们的首要目标是评估女性的 ABPA 病情加重率是否高于男性。我们纳入了 731 名 ABPA 受试者（平均年龄 34.5 岁；49.5% 为女性）。与男性相比，患有 ABPA 的女性年龄更大，患有潜在哮喘的频率更高。男性和女性在肺功能、免疫学检查和影像学检查方面没有差异。发生 ABPA 恶化的女性比例略高于男性（44.5% 对 38.2%），但未达到统计学意义（P = 0.09）。我们没有发现 ABPA 恶化率存在明显的性别差异。前瞻性研究应能证实我们的发现。

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来源期刊

Mycopathologia 生物-真菌学

CiteScore

6.80

自引率

3.60%

发文量

审稿时长

3 months

期刊介绍： Mycopathologia is an official journal of the International Union of Microbiological Societies (IUMS). Mycopathologia was founded in 1938 with the mission to ‘diffuse the understanding of fungal diseases in man and animals among mycologists’. Many of the milestones discoveries in the field of medical mycology have been communicated through the pages of this journal. Mycopathologia covers a diverse, interdisciplinary range of topics that is unique in breadth and depth. The journal publishes peer-reviewed, original articles highlighting important developments concerning medically important fungi and fungal diseases. The journal highlights important developments in fungal systematics and taxonomy, laboratory diagnosis of fungal infections, antifungal drugs, clinical presentation and treatment, and epidemiology of fungal diseases globally. Timely opinion articles, mini-reviews, and other communications are usually invited at the discretion of the editorial board. Unique case reports highlighting unprecedented progress in the diagnosis and treatment of fungal infections, are published in every issue of the journal. MycopathologiaIMAGE is another regular feature for a brief clinical report of potential interest to a mixed audience of physicians and laboratory scientists. MycopathologiaGENOME is designed for the rapid publication of new genomes of human and animal pathogenic fungi using a checklist-based, standardized format.