Magneto-acousto-electrical tomography based on frequency response compensated linearly frequency-modulated signal stimulation.

IF 3.3 3区 医学 Q2 ENGINEERING, BIOMEDICAL Physics in medicine and biology Pub Date : 2024-10-18 DOI:10.1088/1361-6560/ad8296
Meijia Li, Jianfei Wang, Kebin Jia, Zhishen Sun
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Abstract

Objective. In magneto-acousto-electrical tomography (MAET), linearly frequency-modulated (LFM) signal stimulation uses much lower peak voltage than the spike pulse stimulation, lengthening the operation life of the transducer. However, due to the uneven frequency responses of the transducer, the low-noise amplifier (LNA), and the bandpass filter (BPF), MAET using LFM signal stimulation suffers from longitudinal resolution loss. In this paper, frequency response compensated linearly frequency-modulated (FRC-LFM) signal stimulation is investigated to resolve the problem.Approach. The physical model of measurement of the frequency responses of the transducer and the cascading module of the detection electrodes, the LNA, and the BPF is constructed. The frequency responses are approximated by fitting a curve to the measurement data. The frequency response compensation function is set to the reciprocal of the product of the frequency responses. The digital FRC-LFM signal is generated in MATLAB and converted to analog signal through an arbitrary waveform generator. Two groups of MAET experiments are designed to confirm the performance of the FRC-LFM signal stimulation. Pure agar phantom with rectangular through-holes and agar phantom with pork tissue inclusion serve as the samples.Main results. The pulse-compressed magneto-acousto-electrical signal obtained using FRC-LFM stimulation has narrower main-lobe than that obtained using LFM excitation, although the signal to noise pulse interference ratio of the former is little lower than that of the latter, which is due to the limitation of the power amplifier. FRC-LFM also proves to be an effective method to utilize the frequency outside the working band of the transducer in MAET.Significance. The method in this study compensates for the longitudinal resolution loss due to the uneven frequency responses. Combining with high-capability power amplifier and high-performance LNA, the MAET using FRC-LFM signal stimulation can potentially achieve high longitudinal resolution and high sensitivity, advancing MAET toward the clinical application.

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基于频率响应补偿线性频率调制信号刺激的磁声电断层成像。
目的:在磁声电子断层成像(MAET)中,线性频率调制(LFM)信号刺激使用的峰值电压比尖峰脉冲刺激低得多,从而延长了换能器的工作寿命。然而,由于传感器、低噪声放大器(LNA)和带通滤波器(BPF)的频率响应不均匀,使用 LFM 信号刺激的 MAET 存在纵向分辨率损失。本文研究了频率响应补偿线性频率调制(FRC-LFM)信号激励来解决这一问题:方法:构建了测量换能器频率响应的物理模型,以及由检测电极、低噪声放大器和 BPF 组成的级联模块。通过对测量数据进行曲线拟合来近似频率响应。频率响应补偿函数设置为频率响应乘积的倒数。数字 FRC-LFM 信号在 MATLAB 中生成,并通过任意波形发生器转换为模拟信号。为证实 FRC-LFM 信号刺激的性能,设计了两组 MAET 实验。主要结果:主要结果:使用 FRC-LFM 激励获得的脉冲压缩磁声学(MAE)信号比使用 LFM 激励获得的信号主叶更窄,但前者的信噪比脉冲干扰比略低于后者,这是由于功率放大器的限制造成的。事实证明,FRC-LFM 也是在 MAET 中利用传感器工作频带以外频率的有效方法:本研究中的方法弥补了因频率响应不均匀而造成的纵向分辨率损失。结合高性能功率放大器和高性能低噪声放大器,使用 FRC-LFM 信号刺激的 MAET 有可能实现高纵向分辨率和高灵敏度,从而推动 MAET 走向临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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