[Thrombopoietin-mediated regulation of hematopoietic stem cells].

Ayako Nakamura-Ishizu
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Abstract

Sustaining lifelong hematopoiesis requires maintenance, proliferation, and differentiation of hematopoietic stem cells. Thrombopoietin is a cytokine essential for regulation of hematopoietic stem cells as well as differentiation and maturation of megakaryocytes required for platelet production. Due to these properties, thrombopoietin agonists have been used to treat bone marrow failure syndromes such as aplastic anemia. Through analysis of thrombopoietin gene-deficient mice, my colleagues and I have demonstrated the mechanism of action of thrombopoietin receptor agonists in hematopoietic stem cell maintenance and differentiation. This review focuses on governance of homeostasis in the hematopoietic system by thrombopoietin signaling.

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[血小板生成素介导的造血干细胞调节]。
维持终生造血需要造血干细胞的维持、增殖和分化。促血小板生成素是一种细胞因子,对调节造血干细胞以及血小板生成所需的巨核细胞的分化和成熟至关重要。由于这些特性,血小板生成素激动剂已被用于治疗再生障碍性贫血等骨髓衰竭综合症。通过对血小板生成素基因缺陷小鼠的分析,我和我的同事证明了血小板生成素受体激动剂在造血干细胞维持和分化中的作用机制。这篇综述的重点是血小板生成素信号对造血系统稳态的调控。
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[Acquired thrombotic thrombocytopenic purpura during durvalumab monotherapy for non-small cell lung cancer]. [Durable remission of T-cell prolymphocytic leukemia with CLEC16A::IL2 after allogeneic hematopoietic stem cell transplantation]. [Kidney transplantation for end-stage renal disease after third allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia]. [Multiple myeloma with myelofibrosis at diagnosis and aggressive extramedullary relapse after autologous stem cell transplantation].
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