Understanding nuclear mRNA export: Survival under stress

IF 14.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Cell Pub Date : 2024-10-03 DOI:10.1016/j.molcel.2024.08.028
Johanna Franziska Seidler, Katja Sträßer
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Abstract

Nuclear messenger RNA (mRNA) export is vital for cell survival under both physiological and stress conditions. To cope with stress, cells block bulk mRNA export while selectively exporting stress-specific mRNAs. Under physiological conditions, nuclear adaptor proteins recruit the mRNA exporter to the mRNA for export. By contrast, during stress conditions, the mRNA exporter is likely directly recruited to stress-specific mRNAs at their transcription sites to facilitate selective mRNA export. In this review, we summarize our current understanding of nuclear mRNA export. Importantly, we explore insights into the mechanisms that block bulk mRNA export and facilitate transcript-specific mRNA export under stress, highlighting the gaps that still need to be filled.
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了解核 mRNA 的输出:压力下的生存
核信使核糖核酸(mRNA)的输出对于细胞在生理和应激条件下的生存至关重要。为了应对应激,细胞会阻止大量 mRNA 的输出,同时选择性地输出应激特异性 mRNA。在生理条件下,核适配蛋白会将 mRNA 导出器吸引到 mRNA 上进行导出。相比之下,在应激条件下,mRNA导出器很可能直接被招募到应激特异性mRNA的转录位点,以促进mRNA的选择性导出。在这篇综述中,我们总结了目前对核 mRNA 导出的理解。重要的是,我们探讨了应激状态下阻止大量 mRNA 导出和促进转录本特异性 mRNA 导出的机制,并强调了仍需填补的空白。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular Cell
Molecular Cell 生物-生化与分子生物学
CiteScore
26.00
自引率
3.80%
发文量
389
审稿时长
1 months
期刊介绍: Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.
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