Animal-free safety assessment of chemicals: an innovation system perspective.

IF 4.8 2区 医学 Q1 TOXICOLOGY Archives of Toxicology Pub Date : 2024-10-04 DOI:10.1007/s00204-024-03878-0
Marjolein J Hoogstraaten, Jelle Vriend, Victoria C de Leeuw, Simona O Negro, Ellen H M Moors, Anne S Kienhuis, Jarno Hoekman
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Abstract

This perspective paper, which is the result of a collaborative effort between toxicologists and scholars in innovation and transition studies, presents a heuristic framework based on innovation system literature for understanding and appraising mission achievement to animal-free chemical safety assessment using New Approach Methodologies (NAMs). While scientific and technical challenges in this area are relatively well known, the recent establishment of missions and roadmaps to accelerate the acceptance and effective use of NAMs for chemical safety assessment raises new questions about how we can grasp the systemic nature of all changes needed in this transition. This includes recognising broader societal, institutional, and regulatory shifts necessary for NAM acceptance and uptake. Our paper discusses how the innovation system approach offers insights into key processes and associated activities that include as well as transcend the technical and scientific realm, and can help to accelerate acceptance and uptake of NAMs. Based on these insights, we present a comprehensive framework that, next to scientific and technological developments, recognises the need for coordinated efforts in areas like education, training, funding, policy-making, and public engagement to promote the acceptance and uptake of NAMs. Our framework can be used to perform structural and functional analyses of the innovation system of NAMs and animal-free safety assessment and as such provides handholds to track progress and organise collective efforts of actors to make sure we are moving in the right direction.

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不使用动物的化学品安全评估:创新体系视角。
这篇视角论文是毒理学家与创新和转型研究学者合作的成果,它以创新系统文献为基础,提出了一个启发式框架,用于理解和评估使用新方法(NAMs)进行无动物化学安全评估的任务完成情况。虽然这一领域的科学和技术挑战相对众所周知,但最近为加速接受和有效使用新方法评估化学品安全而制定的任务和路线图提出了新的问题,即我们如何才能把握这一过渡所需的所有变革的系统性。这包括认识到更广泛的社会、机构和监管转变对于接受和采用非杀伤人员地雷是必要的。我们的论文讨论了创新系统方法如何为关键流程和相关活动提供见解,这些流程和活动既包括技术和科学领域,也超越技术和科学领域,并有助于加速接受和吸收非杀伤人员地雷。基于这些见解,我们提出了一个综合框架,除科学技术发展外,还认识到需要在教育、培训、资金、政策制定和公众参与等领域协调努力,以促进对非物质文化遗产的接受和吸收。我们的框架可用于对非杀伤人员地雷和无动物安全评估的创新体系进行结构和功能分析,从而为跟踪进展和组织参与者的集体努力提供抓手,以确保我们朝着正确的方向前进。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Archives of Toxicology
Archives of Toxicology 医学-毒理学
CiteScore
11.60
自引率
4.90%
发文量
218
审稿时长
1.5 months
期刊介绍: Archives of Toxicology provides up-to-date information on the latest advances in toxicology. The journal places particular emphasis on studies relating to defined effects of chemicals and mechanisms of toxicity, including toxic activities at the molecular level, in humans and experimental animals. Coverage includes new insights into analysis and toxicokinetics and into forensic toxicology. Review articles of general interest to toxicologists are an additional important feature of the journal.
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