Antibacterial and antibiofilm activity of human gut lactic acid bacteria.

IF 2.1 4区 生物学 Q3 MICROBIOLOGY Brazilian Journal of Microbiology Pub Date : 2024-10-04 DOI:10.1007/s42770-024-01530-8
Sherin Joy Parappilly, E K Radhakrishnan, Sumi Mary George
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Abstract

The present study focused on the antibacterial and antibiofilm activity of novel lactic acid bacterial (LAB) strains isolated from the healthy human volunteers of different age groups and their consortium (LABCON), against the enteropathogenic bacteria. From the study, methanolic extract of LAB isolates and their consortia were found to have promising antibacterial activity and antibiofilm activity against Escherichia coli (ATCC 35218) and Staphylococcus aureus (ATCC 25923). The antimicrobial compounds including the DL-3 phenyllactic acid, DL-p-hydroxyphenyllactic acid, and Succinic acid produced by the LAB could be considered to inhibit the growth and biofilm formation by E. coli (ATCC 35218) and S. aureus (ATCC 25923). Detailed insight into the antibiofilm activity could also be demonstrated by Confocal Raman microscopy attached with AFM and Fluorescent microscope. From the results of the study, the consortium LABCON was superior in antimicrobial and antibiofilm activity and can be considered to have promising application in infection control.

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人体肠道乳酸菌的抗菌和抗生物膜活性。
本研究的重点是从不同年龄组的健康人体志愿者身上分离出的新型乳酸菌(LAB)菌株及其联合体(LABCON)对肠道致病菌的抗菌和抗生物膜活性。研究发现,LAB 分离物及其联合体的甲醇提取物对大肠杆菌(ATCC 35218)和金黄色葡萄球菌(ATCC 25923)具有良好的抗菌活性和抗生物膜活性。酵母菌产生的抗菌化合物包括 DL-3 苯乳酸、DL-对羟基苯乳酸和丁二酸,可用于抑制大肠杆菌(ATCC 35218)和金黄色葡萄球菌(ATCC 25923)的生长和生物膜的形成。通过共焦拉曼显微镜、原子力显微镜和荧光显微镜还可以详细了解抗生物膜活性。从研究结果来看,LABCON 联合菌株在抗菌和抗生物膜活性方面表现出色,有望应用于感染控制领域。
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来源期刊
Brazilian Journal of Microbiology
Brazilian Journal of Microbiology 生物-微生物学
CiteScore
4.10
自引率
4.50%
发文量
216
审稿时长
1.0 months
期刊介绍: The Brazilian Journal of Microbiology is an international peer reviewed journal that covers a wide-range of research on fundamental and applied aspects of microbiology. The journal considers for publication original research articles, short communications, reviews, and letters to the editor, that may be submitted to the following sections: Biotechnology and Industrial Microbiology, Food Microbiology, Bacterial and Fungal Pathogenesis, Clinical Microbiology, Environmental Microbiology, Veterinary Microbiology, Fungal and Bacterial Physiology, Bacterial, Fungal and Virus Molecular Biology, Education in Microbiology. For more details on each section, please check out the instructions for authors. The journal is the official publication of the Brazilian Society of Microbiology and currently publishes 4 issues per year.
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