Effect of perioperative immunonutrition intervention among gynecological cancer patients: A systematic review

IF 2.9 Q3 NUTRITION & DIETETICS Clinical nutrition ESPEN Pub Date : 2024-10-01 DOI:10.1016/j.clnesp.2024.09.022
ChiouYi Ho , Barakatun Nisak Mohd Yusof , Hazreen Abdul Majid , Zulfitri Azuan Mat Daud
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Abstract

Background

Gynecologic cancer (GC) patients often experience systemic inflammation, malnutrition, and compromised postoperative outcomes. This systematic review aims to comprehensively synthesize existing data regarding the impact of perioperative immunonutrition (IMN) intervention on GC patients.

Methods

The databases of CENTRAL, EMBASE, Web of Science, and the Cochrane Library were used to conduct a literature search, supplemented by internet search engines and manual searches. Publications released between January 2009 and October 2023 was identified, reviewed, and data extracted.

Results

The review encompasses six studies involving 712 patients, comprising two randomized controlled trials (RCTs), two prospective studies, and two retrospective cohort studies. Three studies prescribed IMN perioperatively; two pre-operatively and one post-operatively. Four out of six studies reported less post-operative infection and complications. Two studies reported shorter hospitalization using the IMN formula. One study reported a longer hospitalization with IMN supplementation. Overall survival showed no significant difference in the two studies. Four studies reported positive modulation of inflammatory markers and lymphocytes as outcomes, with IMN formulas.

Discussion and conclusion

Perioperative IMN emerge as a promising intervention, demonstrating notable benefits included shortened hospitalization as well and positive modulation of inflammatory markers.
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妇科癌症患者围手术期免疫营养干预的效果:系统回顾
背景:妇科癌症(GC)患者经常会出现全身性炎症、营养不良和术后效果受损。本系统综述旨在全面综合围手术期免疫营养(IMN)干预对 GC 患者影响的现有数据:方法:使用 CENTRAL、EMBASE、Web of Science 和 Cochrane Library 等数据库进行文献检索,并辅以互联网搜索引擎和人工检索。对 2009 年 1 月至 2023 年 10 月间发表的文献进行了识别、审查和数据提取:综述包括六项研究,涉及 712 名患者,其中包括两项随机对照试验 (RCT)、两项前瞻性研究和两项回顾性队列研究。三项研究在围手术期使用 IMN,两项在术前使用,一项在术后使用。六项研究中有四项报告称术后感染和并发症较少。两项研究报告称,使用 IMN 配方的住院时间更短。一项研究报告称,补充 IMN 会延长住院时间。两项研究的总生存率无明显差异。四项研究报告称,IMN配方对炎症标志物和淋巴细胞有积极的调节作用:围手术期 IMN 是一种很有前景的干预措施,其显著的益处包括缩短了住院时间以及对炎症标志物有积极的调节作用。
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来源期刊
Clinical nutrition ESPEN
Clinical nutrition ESPEN NUTRITION & DIETETICS-
CiteScore
4.90
自引率
3.30%
发文量
512
期刊介绍: Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.
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