Consolidating roles of neuroimmune reflexes: specificity of afferent, central, and efferent signals in homeostatic immune networks.

IF 7.5 1区 生物学 Q1 CELL BIOLOGY Genes & development Pub Date : 2024-10-16 DOI:10.1101/gad.352287.124
Kevin J Tracey
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Abstract

Neural reflexes occupy a central role in physiological homeostasis. The vagus nerve is a major conduit for transmitting afferent and efferent signals in homeostatic reflex arcs between the body and the brain. Recent advances in neuroscience, immunology, and physiology have revealed important vagus nerve mechanisms in suppressing inflammation and treating rheumatoid arthritis and other autoimmune conditions. Numerous clinical trials indicate that there is significant benefit to vagus nerve stimulation therapy. Although many questions are still unanswered, it will be important, even necessary, to pursue answers that will be useful in guiding interventions to modulate immunological and physiological homeostasis.

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巩固神经免疫反射的作用:同源免疫网络中传入、中枢和传出信号的特异性。
神经反射在生理平衡中起着核心作用。迷走神经是人体与大脑之间的平衡反射弧中传递传入和传出信号的主要通道。神经科学、免疫学和生理学的最新进展揭示了迷走神经在抑制炎症、治疗类风湿性关节炎和其他自身免疫性疾病方面的重要机制。大量临床试验表明,迷走神经刺激疗法有显著疗效。尽管许多问题仍未得到解答,但寻找答案将是重要的,甚至是必要的,这些答案将有助于指导干预措施,以调节免疫和生理平衡。
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来源期刊
Genes & development
Genes & development 生物-发育生物学
CiteScore
17.50
自引率
1.90%
发文量
71
审稿时长
3-6 weeks
期刊介绍: Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).
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