Application Characteristics and Patient Preference of Triple-Combination vs Layered Topicals for Acne: Split-Face Study.

IF 1.5 4区 医学 Q3 DERMATOLOGY Journal of Drugs in Dermatology Pub Date : 2024-10-01 DOI:10.36849/JDD.2024.8430
Zoe D Draelos
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Abstract

Background: Although triple-combination therapies for acne are generally more efficacious than dual-combinations or topical monotherapy, this benefit may be offset by reduced adherence to a complicated treatment regimen. Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB; Cabtreo®, Ortho Dermatologics) gel is the first triple-combination topical approved for the treatment of acne. By delivering multiple active ingredients as a fixed-dose combination, CAB gel may improve ease of use, which can benefit both treatment adherence and efficacy. The objective of this study was to compare the application characteristics of CAB gel with the layered application of its 3 individual active ingredients.

Methods: In this split-face study, adults with acne-prone skin (N=25), self-applied CAB gel (0.3 cc) to 1 side of the face and layered benzoyl peroxide cream, adapalene gel, and clindamycin gel (0.1 cc each) on the opposite side. CAB and clindamycin gels were compounded with pyranine, which fluoresces under blue light. Photos taken under blue light were used to assess the uniformity of product application, and participants rated the evenness, speed, and ease of the 2 application regimens, as well as overall preference.

Results: Investigator-assessed evenness of application favored CAB gel over layered application in 100% of participants. All participants rated the application of CAB gel as more uniform, easier, and faster. Most (96%) preferred CAB gel for use at home.

Conclusion: Fixed-dose CAB gel was applied more evenly than separate application of its 3 active ingredients. By addressing 3 of the main acne pathogenic pathways in a single, easy-to-apply formulation, CAB gel may improve the efficacy of and adherence to acne treatment. J Drugs Dermatol. 2024;23(10):857-861. doi:10.36849/JDD.8430.

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三合一外用药与分层外用药治疗痤疮的应用特点和患者偏好:分面研究。
背景:虽然三联疗法治疗痤疮的疗效通常高于二联疗法或局部单药疗法,但这种优势可能会因患者对复杂治疗方案的依从性降低而被抵消。克林霉素磷酸酯 1.2%/阿达帕林 0.15%/过氧化苯甲酰 3.1%(CAB;Cabtreo®;,Ortho Dermatologics)凝胶是首款获准用于治疗痤疮的三合一外用药。CAB 凝胶以固定剂量组合的方式提供多种活性成分,可以提高使用的简便性,从而有利于治疗的依从性和疗效。本研究的目的是比较 CAB 凝胶与 3 种单独活性成分分层涂抹的涂抹特性:在这项分脸研究中,患有痤疮的成年人(25 人)在脸的一侧自行涂抹 CAB 凝胶(0.3 cc),并在另一侧分层涂抹过氧化苯甲酰乳膏、阿达帕林凝胶和克林霉素凝胶(各 0.1 cc)。CAB 和克林霉素凝胶与吡喃宁复配,吡喃宁在蓝光下会发出荧光。在蓝光下拍摄的照片用于评估产品涂抹的均匀性,参与者对两种涂抹方法的均匀性、速度、简便性以及总体偏好进行评分:结果:100% 的受试者都认为 CAB 凝胶的涂抹均匀度优于分层涂抹。所有参与者都认为使用 CAB 凝胶更均匀、更容易和更快。大多数人(96%)更喜欢在家中使用 CAB 凝胶:结论:固定剂量的 CAB 凝胶比单独使用其 3 种活性成分更均匀。CAB凝胶以单一、易涂抹的配方解决了痤疮的3种主要致病途径,可提高痤疮治疗的疗效和依从性。J Drugs Dermatol.2024;23(10):857-861. doi:10.36849/JDD.8430.
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来源期刊
CiteScore
2.20
自引率
13.30%
发文量
289
审稿时长
3-6 weeks
期刊介绍: The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology. We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality. Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.
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