Physical activity and risk of Parkinson's disease: an updated systematic review and meta-analysis.

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY Journal of Neurology Pub Date : 2024-10-03 DOI:10.1007/s00415-024-12672-y
Yanjie Jiang, Shipeng Zhang, Yuecan Chen, Hanyu Wang, Xingyi He, Chengli Bin, Rui Fu, Huan Wang, Hanqi Zhu, Moshen Pan, Qinxiu Zhang, Yan Lu
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Abstract

Background and objectives: Although recent meta-analyses have shown that the association between physical activity (PA) and the risk of developing Parkinson's disease (PD) is influenced by gender differences, a growing number of studies are revealing the general applicability of this association across genders. This study aimed to reassess the association and dose-response relationship between PA and PD risk in populations.

Methods: A systematic search of PubMed, Embase, Cochrane Library, and Web of Science databases was conducted in this study from inception to February 1, 2024, without language restrictions. Stratified analyses were conducted to explore the association between PA and PD risk, combining multivariate-adjusted effect estimates via random-effects models, and to validate the dose-response relationship between the two.

Results: This study included 21 observational studies, comprising 13 cohort studies and 8 case-control studies. The pooled analysis revealed that PA significantly reduced the risk of developing PD [relative risk (RR) = 0.77, 95% CI 0.70-0.85]. In addition, the dose-response analysis revealed both linear and nonlinear associations, with linear results indicating a 9% reduction in PD risk for every 10 MET-h/wk increase in PA. The study also demonstrated that the protective effect of PA against PD was significant for both sexes. Moreover, no statistically significant effects of PA on preventing PD were observed in individuals with a BMI > 26 (RR = 0.35, 95% CI 0.12-1.02) or in Asian populations (RR = 0.78, 95% CI 0.60-1.01); however, the trends suggest potential protective effects, warranting further investigation. Sensitivity analyses confirmed the robustness of these findings.

Conclusion: This meta-analysis produced substantial evidence to reaffirm the protective effect of high PA on PD across various population groups and the inverse dose-response relationship with PD risk, and to validate the protective effect of PA among different demographic groups.

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体育锻炼与帕金森病的风险:最新的系统综述和荟萃分析。
背景和目的:尽管最近的荟萃分析表明,体力活动(PA)与帕金森病(PD)发病风险之间的关联受性别差异的影响,但越来越多的研究揭示了这种关联在不同性别间的普遍适用性。本研究旨在重新评估人群中 PA 与帕金森病风险之间的关联和剂量反应关系:本研究对 PubMed、Embase、Cochrane Library 和 Web of Science 数据库进行了系统检索,检索时间从开始至 2024 年 2 月 1 日,无语言限制。通过随机效应模型结合多变量调整效应估计值,进行分层分析以探讨PA与PD风险之间的关系,并验证两者之间的剂量-反应关系:本研究纳入了 21 项观察性研究,包括 13 项队列研究和 8 项病例对照研究。汇总分析显示,PA 能显著降低罹患帕金森病的风险[相对风险 (RR) = 0.77,95% CI 0.70-0.85]。此外,剂量反应分析显示了线性和非线性关联,线性结果表明,PA 每增加 10 MET-h/wk,患帕金森病的风险就会降低 9%。研究还表明,PA 对帕金森病的保护作用对男女均有显著影响。此外,在体重指数大于 26 的人群(RR = 0.35,95% CI 0.12-1.02)或亚洲人群(RR = 0.78,95% CI 0.60-1.01)中,没有观察到 PA 对预防帕金森病有统计学意义的影响;但是,趋势表明 PA 有潜在的保护作用,值得进一步研究。敏感性分析证实了这些结果的稳健性:这项荟萃分析提供了大量证据,再次证实了高PA在不同人群中对PD的保护作用,以及与PD风险之间的剂量-反应反比关系,并验证了PA在不同人口群体中的保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Neurology
Journal of Neurology 医学-临床神经学
CiteScore
10.00
自引率
5.00%
发文量
558
审稿时长
1 months
期刊介绍: The Journal of Neurology is an international peer-reviewed journal which provides a source for publishing original communications and reviews on clinical neurology covering the whole field. In addition, Letters to the Editors serve as a forum for clinical cases and the exchange of ideas which highlight important new findings. A section on Neurological progress serves to summarise the major findings in certain fields of neurology. Commentaries on new developments in clinical neuroscience, which may be commissioned or submitted, are published as editorials. Every neurologist interested in the current diagnosis and treatment of neurological disorders needs access to the information contained in this valuable journal.
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