Lineage and sublineage analysis of human papillomavirus type 58 in iranian women.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2024-10-03 DOI:10.1186/s12985-024-02521-9

Mohammad Shabanpour, Parvin Jalali-Alhosseini, Zabihollah Shoja, Fatemeh Ghafoori-Ghahdarijani, Sima Taherkhani, Somayeh Jalilvand

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Abstract

Background: Variant analysis of distinct HPV types is important from different aspects including epidemiology, pathogenicity, and evolution.

Methods: For this reason, the full sequence of the E6 and E7 genes of HPV 58 was examined in 130 HPV 58-infected cervical samples using PCR and sequencing.

Results: Our results revealed that three lineages A, B, and D were found in this study; among which the B lineage was more common (91.50%). About sublineages, all samples of the B lineage belonged to the B1 sublineage, and samples that were classified as the A and D lineages were found to belong to the A1 (0.77%), A2 (5.38%), A3 (1.50%), and D2 (0.77%) sublineages. No statistically significant differences were found between lineages and stages of disease or amino acid changes (P > 0.05).

Conclusion: Our results showed that lineage B, sublineage B1, was dominant in Iran. However, more studies with larger sample sizes from different parts of Iran are essential for assessing the pathogenicity risk of HPV 58 lineages in Iranian women with cervical cancer.

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伊朗妇女中人类乳头瘤病毒 58 型的系谱和亚系谱分析。

背景：从流行病学、致病性和进化等不同方面对不同类型的 HPV 进行变异分析非常重要：为此，我们利用 PCR 和测序技术对 130 例感染 HPV 58 的宫颈样本进行了 HPV 58 E6 和 E7 基因全序列检测：结果：我们的研究结果显示，本研究中发现了 A、B 和 D 三个系；其中 B 系更为常见（91.50%）。关于亚系，B 系的所有样本都属于 B1 亚系，被归类为 A 和 D 系的样本分别属于 A1（0.77%）、A2（5.38%）、A3（1.50%）和 D2（0.77%）亚系。各系与疾病阶段或氨基酸变化之间无统计学差异（P > 0.05）：我们的研究结果表明，B系（B1亚系）在伊朗占主导地位。然而，要评估伊朗妇女宫颈癌患者中 HPV 58 系的致病风险，必须在伊朗不同地区开展更多样本量更大的研究。

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.