Bianca Grosser, Nic G Reitsam, Przmyslaw Grochowski, Lukas Rentschler, Johanna Enke, Bruno Märkl
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引用次数: 0
Abstract
A stroma a‑reactive invasion front area (SARIFA) is a new prognostic biomarker in carcinomas. Essentially, SARIFA describes the occurrence of direct contact between at least five tumor cells and adipocytes. This phenomenon is extremely easy and quick to identify, shows an extremely low interobserver variability, and does not require any additional staining as it can be identified on standard HE sections. The prognostic efficiency has now been demonstrated in gastric, colorectal, pancreatic, and prostate carcinoma.
基质反应性侵袭前区（SARIFA）是一种新的癌症预后生物标志物。从本质上讲，SARIFA 描述了至少五个肿瘤细胞与脂肪细胞之间发生的直接接触。这种现象非常容易快速识别，观察者之间的可变性极低，而且不需要任何额外的染色，因为它可以在标准的 HE 切片上识别出来。这种预后效果现已在胃癌、结直肠癌、胰腺癌和前列腺癌中得到证实。
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