Mechanisms linking prenatal environment and linear growth: the case of Ramadan during pregnancy.

IF 5 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH American journal of epidemiology Pub Date : 2024-10-04 DOI:10.1093/aje/kwae386
Fabienne Pradella, Reyn Ewijk
{"title":"Mechanisms linking prenatal environment and linear growth: the case of Ramadan during pregnancy.","authors":"Fabienne Pradella, Reyn Ewijk","doi":"10.1093/aje/kwae386","DOIUrl":null,"url":null,"abstract":"<p><p>Despite established links between prenatal nutritional deprivation and impaired offspring growth, the underlying dynamics and potential moderators remain largely unexplored. This study investigates the dynamics underlying Ramadan during pregnancy and its associations with children's linear growth, using data from the Indonesian Family Life Survey (1993 - 2015). We exploit Ramadan during pregnancy as a natural experiment, separating exposure from maternal background characteristics and season of birth effects. Employing OLS and logistic regressions, we explore two key mechanisms predicted by medical theory. First, the realization of health impairments in response to prenatal shocks is influenced by postnatal circumstances. Our results reveal significant growth impairments primarily in children raised under poor sanitary conditions, which is a risk factor for diminished linear growth by itself. Secondly, we assess whether prenatal Ramadan prompts epigenetic shifts towards earlier reproductive activity, potentially at the expense of height growth. Our data shows that prenatally exposed women tend to have their first childbirth at a younger age, though menarche onset remains unaffected. These results suggest that postnatal environments play a crucial role in mitigating sensitivity to prenatal shocks, highlighting the critical need for favorable living conditions for all children.</p>","PeriodicalId":7472,"journal":{"name":"American journal of epidemiology","volume":" ","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of epidemiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/aje/kwae386","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0

Abstract

Despite established links between prenatal nutritional deprivation and impaired offspring growth, the underlying dynamics and potential moderators remain largely unexplored. This study investigates the dynamics underlying Ramadan during pregnancy and its associations with children's linear growth, using data from the Indonesian Family Life Survey (1993 - 2015). We exploit Ramadan during pregnancy as a natural experiment, separating exposure from maternal background characteristics and season of birth effects. Employing OLS and logistic regressions, we explore two key mechanisms predicted by medical theory. First, the realization of health impairments in response to prenatal shocks is influenced by postnatal circumstances. Our results reveal significant growth impairments primarily in children raised under poor sanitary conditions, which is a risk factor for diminished linear growth by itself. Secondly, we assess whether prenatal Ramadan prompts epigenetic shifts towards earlier reproductive activity, potentially at the expense of height growth. Our data shows that prenatally exposed women tend to have their first childbirth at a younger age, though menarche onset remains unaffected. These results suggest that postnatal environments play a crucial role in mitigating sensitivity to prenatal shocks, highlighting the critical need for favorable living conditions for all children.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
产前环境与线性生长的关联机制:孕期斋月的案例。
尽管产前营养匮乏与后代生长受损之间已建立了联系,但其背后的动态变化和潜在的调节因素在很大程度上仍未得到探讨。本研究利用印度尼西亚家庭生活调查(1993-2015 年)的数据,研究了孕期斋月的基本动态及其与儿童线性生长的关系。我们利用孕期斋月作为自然实验,将暴露与母亲背景特征和出生季节效应分离开来。利用 OLS 和逻辑回归,我们探讨了医学理论预测的两个关键机制。首先,产前冲击所导致的健康损害会受到产后环境的影响。我们的研究结果表明,在卫生条件差的环境中长大的儿童主要会出现明显的生长障碍,而卫生条件差本身就是导致线性生长减弱的一个风险因素。其次,我们评估了产前斋月是否会促使表观遗传学转向更早的生殖活动,从而可能牺牲身高的增长。我们的数据显示,产前受到斋月影响的妇女倾向于在更年轻的年龄生育第一胎,尽管初潮的到来不受影响。这些结果表明,产后环境在减轻对产前冲击的敏感性方面起着至关重要的作用,突出了为所有儿童提供良好生活条件的迫切需要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
American journal of epidemiology
American journal of epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
7.40
自引率
4.00%
发文量
221
审稿时长
3-6 weeks
期刊介绍: The American Journal of Epidemiology is the oldest and one of the premier epidemiologic journals devoted to the publication of empirical research findings, opinion pieces, and methodological developments in the field of epidemiologic research. It is a peer-reviewed journal aimed at both fellow epidemiologists and those who use epidemiologic data, including public health workers and clinicians.
期刊最新文献
All-Cause Mortality and 1990-1991 Gulf War Service within the Millennium Cohort Study (2001-2021). Using Double Negative Controls to Adjust for Healthy User Bias in a Recombinant Zoster Vaccine Safety Study. Modern Sources of Controls in Case-Control Studies. Editorial consultants 1. Characterizing state-level structural cisheterosexism trajectories using sequence and cluster analysis, 1996-2016, 50 U.S. states and Washington, D.C., and associations with health status and healthcare outcomes.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1