The prognostic role of whole-body volumetric positron emission tomography/computed tomography parameters in treatment naive colorectal cancer patients with liver metastases.

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Nuclear Medicine Communications Pub Date : 2024-10-02 DOI:10.1097/MNM.0000000000001915
Hüseyin Karaoğlan, Ferat Kepenek, Halil Kömek, İhsan Kaplan, Ömer Yeprem, Ridvan Kaya, Yunus Güzel, Veysi Şenses, Fulya Kaya İpek, Canan Can
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Abstract

Purpose: The present study aimed to predict the prognostic role of quantitative 18F-fluorodeoxyglucose PET/computed tomography parameters such as maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) obtained from primary tumor, lymph node metastases, and liver metastasis (LM) in patients with colorectal LM (CLM).

Material and method: The research was designed as a retrospective study and 66 patients with CLM were enrolled between January 2017 and December 2018. Primary tumor SUVmax (PSUVmax), liver SUVmax (LSUVmax), and lymph node SUVmax (LnSUVmax) values obtained from the primary tumor, liver, and lymph nodes were recorded. In addition, total MTV (TMTV) and total TLG (TTLG) values were obtained by summing the values obtained from the primary tumor (PMTV and PTLG), lymph nodes (LnMTV and LnTLG), and liver (LMTV and LTLG). Univariate and multivariate Cox regression analysis was used to measure the effects of prognostic variables on mortality and survival.

Result: In univariate Cox regression analysis, PMTV (P = 0.001), LnMTV (P = 0.008), LnTLG (P = 0.008), LnSUVmax (P = 0.047), and TTLG (P = 0.038) were identified as prognostic factors for overall survival. No statistically significant relationship was found between MTV and TLG values of LM and overall survival. In multivariate analysis, PMTV (P = 0.022) was identified as an independent prognostic factor.

Conclusion: In conclusion, our study demonstrated that the PMTV value used in evaluating treatment-naive patients diagnosed with CLM is an independent prognostic factor for survival. Our results need to be confirmed with more studies involving more patients.

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全身容积正电子发射断层扫描/计算机断层扫描参数在肝转移的治疗稚嫩结直肠癌患者中的预后作用。
目的:本研究旨在预测从原发肿瘤、淋巴结转移灶和肝转移灶(LM)获取的18F-氟脱氧葡萄糖PET/计算机断层扫描定量参数,如最大标准化摄取值(SUVmax)、代谢肿瘤体积(MTV)和总病变糖酵解(TLG)对结直肠癌LM(CLM)患者的预后作用:该研究设计为回顾性研究,在2017年1月至2018年12月期间共纳入66例CLM患者。记录从原发肿瘤、肝脏和淋巴结获得的原发肿瘤 SUVmax(PSUVmax)、肝脏 SUVmax(LSUVmax)和淋巴结 SUVmax(LnSUVmax)值。此外,原发肿瘤(PMTV 和 PTLG)、淋巴结(LnMTV 和 LnTLG)和肝脏(LMTV 和 LTLG)的总 MTV(TMTV)和总 TLG(TTLG)值相加得出。采用单变量和多变量 Cox 回归分析来衡量预后变量对死亡率和生存率的影响:结果:在单变量 Cox 回归分析中,PMTV(P = 0.001)、LnMTV(P = 0.008)、LnTLG(P = 0.008)、LnSUVmax(P = 0.047)和 TTLG(P = 0.038)被确定为总生存率的预后因素。在 LM 的 MTV 和 TLG 值与总生存率之间未发现有统计学意义的关系。在多变量分析中,PMTV(P = 0.022)被认为是一个独立的预后因素:总之,我们的研究表明,用于评估诊断为CLM的治疗无效患者的PMTV值是一个独立的生存预后因素。我们的研究结果需要更多患者参与的更多研究来证实。
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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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