Epidemiological Characteristics of Upper Respiratory Tract Pathogens in Children in Guangdong, China

IF 1.9 4区 医学 Q3 RESPIRATORY SYSTEM Clinical Respiratory Journal Pub Date : 2024-10-05 DOI:10.1111/crj.70011
Qianwen Zhao, Peifeng Ke, Liangshan Hu, Changhong Jiang, Rong Su, Weifeng Lv, Qixin Li, Lingxiao Jiang, Donglin Cao
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Abstract

Objective

Researches on the epidemiology of various respiratory pathogens at multiple testing points in the pediatric population are limited, and these are crucial for the prevention of respiratory tract infections in children.

Methods

We obtained 1788 upper respiratory tract swabs from children exhibiting symptoms of respiratory infection (notably fever with a body temperature exceeding 38.5°C) across five hospitals in Guangdong between November 2020 and June 2022. We used the multiplex probe amplification (MPA) PCR testing to identify 11 respiratory viruses and subsequently analyzed the prevalence characteristics of these pathogens among febrile children in hospitals.

Results

The overall detection rate of the pathogens was 58.1% (1039/1788). Human rhinovirus (HRV) exhibited the highest detection rate at 19.0% (339/1788), succeeded by human parainfluenza virus (HPIV), human adenovirus (HAdV), and respiratory syncytial virus (RSV). The positivity and coinfection rates were higher in children aged 5 years and below compared to those above 5 years. Moreover, a distinct pathogen spectrum was observed across different age groups. Hospitalized patients demonstrated a significantly higher positivity and coinfection rate compared to outpatients. During COVID-2019, RSV appeared a counter-seasonal trend.

Conclusion

Respiratory viral infections in children display distinct characteristics concerning age, hospitalization status, and seasonality. Children under the age of 5 and minor patients admitted to hospitals at least be tested for RSV, HRV, HPIV, and HAdV. The epidemiological patterns of RSV in the post-epidemic period require ongoing surveillance.

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中国广东省儿童上呼吸道病原体的流行病学特征。
摘要对儿科人群中多个检测点的各种呼吸道病原体的流行病学研究有限,而这些研究对预防儿童呼吸道感染至关重要:2020年11月至2022年6月期间,我们在广东省5家医院采集了1788名有呼吸道感染症状(主要是发热,体温超过38.5°C)的儿童的上呼吸道拭子。我们采用多重探针扩增(MPA)PCR检测方法鉴定了11种呼吸道病毒,随后分析了这些病原体在医院发热儿童中的流行特征:结果:病原体的总体检出率为58.1%(1039/1788)。人鼻病毒(HRV)的检出率最高,为 19.0%(339/1788),其次是人副流感病毒(HPIV)、人腺病毒(HAdV)和呼吸道合胞病毒(RSV)。与 5 岁以上儿童相比,5 岁及以下儿童的阳性率和合并感染率更高。此外,不同年龄组的病原体谱各不相同。与门诊患者相比,住院患者的阳性率和合并感染率明显更高。在 COVID-2019 期间,RSV 出现了反季节趋势:儿童呼吸道病毒感染在年龄、住院情况和季节性方面表现出明显的特征。5岁以下儿童和住院的未成年患者至少要检测RSV、HRV、HPIV和HAdV。需要对流行后时期 RSV 的流行模式进行持续监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Respiratory Journal
Clinical Respiratory Journal 医学-呼吸系统
CiteScore
3.70
自引率
0.00%
发文量
104
审稿时长
>12 weeks
期刊介绍: Overview Effective with the 2016 volume, this journal will be published in an online-only format. Aims and Scope The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic. We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including: Asthma Allergy COPD Non-invasive ventilation Sleep related breathing disorders Interstitial lung diseases Lung cancer Clinical genetics Rhinitis Airway and lung infection Epidemiology Pediatrics CRJ provides a fast-track service for selected Phase II and Phase III trial studies. Keywords Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease, Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Embase (Elsevier) Health & Medical Collection (ProQuest) Health Research Premium Collection (ProQuest) HEED: Health Economic Evaluations Database (Wiley-Blackwell) Hospital Premium Collection (ProQuest) Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) ProQuest Central (ProQuest) Science Citation Index Expanded (Clarivate Analytics) SCOPUS (Elsevier)
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