Gastrointestinal cancer resistance to treatment: the role of microbiota.

IF 3.1 2区医学 Q3 IMMUNOLOGY Infectious Agents and Cancer Pub Date : 2024-10-05 DOI:10.1186/s13027-024-00605-3

Leila Kolahi Sadeghi, Fatemeh Vahidian, Majid Eterafi, Elham Safarzadeh

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Abstract

The most common illnesses that adversely influence human health globally are gastrointestinal malignancies. The prevalence of gastrointestinal cancers (GICs) is relatively high, and the majority of patients receive ineffective care since they are discovered at an advanced stage of the disease. A major component of the human body is thought to be the microbiota of the gastrointestinal tract and the genes that make up the microbiome. The gut microbiota includes more than 3000 diverse species and billions of microbes. Each of them has benefits and drawbacks and been demonstrated to alter anticancer medication efficacy. Treatment of GIC with the help of the gut bacteria is effective while changes in the gut microbiome which is linked to resistance immunotherapy or chemotherapy. Despite significant studies and findings in this field, more research on the interactions between microbiota and response to treatment in GIC are needed to help researchers provide more effective therapeutic strategies with fewer treatment complication. In this review, we examine the effect of the human microbiota on anti-cancer management, including chemotherapy, immunotherapy, and radiotherapy.

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胃肠道癌症的抗药性：微生物群的作用。

对全球人类健康产生不利影响的最常见疾病是胃肠道恶性肿瘤。胃肠道癌症（GICs）的发病率相对较高，大多数患者由于在疾病晚期才被发现，因此治疗效果不佳。人体的一个主要组成部分被认为是胃肠道的微生物群和组成微生物群的基因。肠道微生物群包括 3000 多种不同的物种和数十亿种微生物。它们各有利弊，并被证明可以改变抗癌药物的疗效。借助肠道细菌治疗 GIC 是有效的，而肠道微生物群的变化与抗药性免疫疗法或化疗有关。尽管在这一领域有大量研究和发现，但仍需要对 GIC 中微生物群与治疗反应之间的相互作用进行更多研究，以帮助研究人员提供更有效的治疗策略，减少治疗并发症。在本综述中，我们将探讨人类微生物群对化疗、免疫疗法和放疗等抗癌治疗的影响。

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来源期刊

Infectious Agents and Cancer ONCOLOGY-IMMUNOLOGY

CiteScore

5.80

自引率

2.70%

发文量

期刊介绍： Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer. The journal welcomes submissions in the pathogen-related cancer areas and other related topics, in particular: • HPV and anogenital cancers, as well as head and neck cancers; • EBV and Burkitt lymphoma; • HCV/HBV and hepatocellular carcinoma as well as lymphoproliferative diseases; • HHV8 and Kaposi sarcoma; • HTLV and leukemia; • Cancers in Low- and Middle-income countries. The link between infection and cancer has become well established over the past 50 years, and infection-associated cancer contribute up to 16% of cancers in developed countries and 33% in less developed countries. Preventive vaccines have been developed for only two cancer-causing viruses, highlighting both the opportunity to prevent infection-associated cancers by vaccination and the gaps that remain before vaccines can be developed for other cancer-causing agents. These gaps are due to incomplete understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause cancer, the mechanisms they exploit to cause cancer, and how to interrupt progression to cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies.