Subclinical left ventricular dysfunction and laboratory predictor of activity in children with ulcerative colitis: A single-centre study.

IF 1.6 4区 医学 Q2 PEDIATRICS Journal of paediatrics and child health Pub Date : 2024-10-05 DOI:10.1111/jpc.16681
Ahmed Said Behairy, Gehan Hussein, Ahmed Afifi, Mary Michel, Amera M Hasnoon
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Abstract

Aim: We aimed to detect subclinical cardiac impairment in children with ulcerative colitis (UC) and test the association between absolute monocytic count (AMC) and lymphocyte-to-monocyte ratio (LMR) with disease activity.

Methods: A group of children with UC and a comparable group as healthy controls were included. All children underwent history-taking, clinical examination and blood testing for complete blood counts with white blood cell differentials, LMR and erythrocyte sedimentation rate (ESR). Disease severity was assessed using the Paediatric UC Activity Index score. We used echocardiography for tissue Doppler, M-Mode, two-dimensional and three-dimensional (3D) speckle tracking echocardiography (STE) for left ventricular function assessment.

Results: Forty children were included, 20 with UC as cases, and 20 healthy controls. Disease activity was mild in 75% cases and moderate in 25% cases. Cases had significantly higher ESR than the control group (P < 0.001). Among cases, positive correlations were observed between monocytic, and platelet counts with left ventricular end-diastolic diameter (r = 0.5, P = 0.02; r = 0.5, P = 0.03). Children with UC had significantly lower ejection fraction and impaired left ventricular systolic function compared to the control group (P < 0.001) assessed by 3D STE, yet this observation was not reached by the conventional method (P = 0.3).

Conclusions: In children with UC, 3D STE could detect subclinical left ventricular systolic dysfunction that conventional echocardiography could not. AMC and LMR showed no significant difference between children with UC and controls.

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亚临床左心室功能障碍和溃疡性结肠炎患儿活动的实验室预测因子:单中心研究
目的:我们旨在检测溃疡性结肠炎(UC)患儿的亚临床心脏功能损害,并检验单核细胞绝对计数(AMC)和淋巴细胞与单核细胞比值(LMR)与疾病活动性之间的关联:方法:纳入一组 UC 患儿和一组健康对照组。所有儿童均接受了病史采集、临床检查和血液检测,包括全血细胞计数和白细胞差值、淋巴细胞与单核细胞比值(LMR)和红细胞沉降率(ESR)。疾病严重程度采用儿科 UC 活动指数评分进行评估。我们使用超声心动图进行组织多普勒、M型、二维和三维斑点追踪超声心动图(STE)评估左心室功能:共纳入 40 名儿童,其中 20 名为 UC 病例,20 名为健康对照组。75%的病例有轻度疾病活动,25%的病例有中度疾病活动。病例组的血沉明显高于对照组(P在 UC 患儿中,三维 STE 可检测出亚临床左心室收缩功能障碍,而传统超声心动图则无法检测。AMC 和 LMR 在 UC 患儿和对照组之间无明显差异。
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来源期刊
CiteScore
2.90
自引率
5.90%
发文量
487
审稿时长
3-6 weeks
期刊介绍: The Journal of Paediatrics and Child Health publishes original research articles of scientific excellence in paediatrics and child health. Research Articles, Case Reports and Letters to the Editor are published, together with invited Reviews, Annotations, Editorial Comments and manuscripts of educational interest.
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