A novel approach to investigate the mechanism of electroconvulsive therapy in the treatment of major depression disorder: Diffusion kurtosis imaging

IF 3.7 2区 医学 Q1 PSYCHIATRY Journal of psychiatric research Pub Date : 2024-09-24 DOI:10.1016/j.jpsychires.2024.09.036
Jing Yang , Ping Tong , Li-Ping Dong, Yuan-Hong Shi
{"title":"A novel approach to investigate the mechanism of electroconvulsive therapy in the treatment of major depression disorder: Diffusion kurtosis imaging","authors":"Jing Yang ,&nbsp;Ping Tong ,&nbsp;Li-Ping Dong,&nbsp;Yuan-Hong Shi","doi":"10.1016/j.jpsychires.2024.09.036","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Major depression disorder (MDD) exhibits a high global incidence; however, its pathogenesis remains elusive. In this prospective study, we employed diffusion kurtosis imaging (DKI) to investigate changes in brain function among patients with MDD both pre- and post-electroconvulsive therapy (ECT).</div></div><div><h3>Methods</h3><div>We divided a sample of 22 MDD patients into ECT group, which received six treatments over a span of two weeks, and control group (<em>n</em> = 12). DKI scanning was performed before and after treatment. The Hamilton Depression Rating Scale (HAMD) and Life Satisfaction Rating Scale (LSRS) were administered to assess depressive symptoms at baseline, on the 14th day, and at month three.</div></div><div><h3>Results</h3><div>Significant differences were found between group, time and time × group in terms of HAMD score and LSRS score. In the ECT group compared to pre- ECT measurement, changes in mean diffusivity (MD), fractional Anisotropy (FA), mean kurtosis (MK), radial kurtosis (RK), FA of kurtosis (KA), and anxia kurtosis (AK) value were detected in specific regions such as the frontal, temporal lobe, and hippocampus. In the control group only MD and RK value increased in a limited number of area.</div></div><div><h3>Conclusions</h3><div>ECT holds the potential to elicit neuroplasticity in the brain, facilitating rapid structural modifications and amelioration of depressive symptoms in patients with MDD.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"179 ","pages":"Pages 372-378"},"PeriodicalIF":3.7000,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of psychiatric research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022395624005594","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Major depression disorder (MDD) exhibits a high global incidence; however, its pathogenesis remains elusive. In this prospective study, we employed diffusion kurtosis imaging (DKI) to investigate changes in brain function among patients with MDD both pre- and post-electroconvulsive therapy (ECT).

Methods

We divided a sample of 22 MDD patients into ECT group, which received six treatments over a span of two weeks, and control group (n = 12). DKI scanning was performed before and after treatment. The Hamilton Depression Rating Scale (HAMD) and Life Satisfaction Rating Scale (LSRS) were administered to assess depressive symptoms at baseline, on the 14th day, and at month three.

Results

Significant differences were found between group, time and time × group in terms of HAMD score and LSRS score. In the ECT group compared to pre- ECT measurement, changes in mean diffusivity (MD), fractional Anisotropy (FA), mean kurtosis (MK), radial kurtosis (RK), FA of kurtosis (KA), and anxia kurtosis (AK) value were detected in specific regions such as the frontal, temporal lobe, and hippocampus. In the control group only MD and RK value increased in a limited number of area.

Conclusions

ECT holds the potential to elicit neuroplasticity in the brain, facilitating rapid structural modifications and amelioration of depressive symptoms in patients with MDD.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
研究电休克疗法治疗重度抑郁症机制的新方法:扩散峰度成像
背景:重度抑郁障碍(MDD)在全球的发病率很高;然而,其发病机制仍然难以捉摸。在这项前瞻性研究中,我们采用弥散峰度成像(DKI)研究了电休克疗法(ECT)前后重度抑郁症患者大脑功能的变化:我们将 22 名 MDD 患者分为电休克治疗组(两周内接受六次治疗)和对照组(12 人)。在治疗前后进行 DKI 扫描。汉密尔顿抑郁量表(HAMD)和生活满意度量表(LSRS)用于评估基线、第14天和第3个月时的抑郁症状:在 HAMD 评分和 LSRS 评分方面,发现组间、时间间和时间×组间存在显著差异。与电痉挛治疗前的测量结果相比,电痉挛治疗组的额叶、颞叶和海马等特定区域的平均弥散度(MD)、分数各向异性(FA)、平均峰度(MK)、径向峰度(RK)、峰度的FA(KA)和缺失峰度(AK)值均发生了变化。在对照组中,只有少数区域的 MD 和 RK 值有所增加:结论:电痉挛疗法具有激发大脑神经可塑性的潜力,有助于快速改变 MDD 患者的结构并改善其抑郁症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of psychiatric research
Journal of psychiatric research 医学-精神病学
CiteScore
7.30
自引率
2.10%
发文量
622
审稿时长
130 days
期刊介绍: Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;
期刊最新文献
The mediating role of depression and disability in the association between widowhood and cognitive function among elderly Chinese individuals. Non-attendance in randomized remote mental health clinical trial during the COVID-19 pandemic Clinical and lifestyle predictors of loneliness: A two-year longitudinal study Parental mental disorders and ages of onset of severe mental disorders in offspring: A nationwide family-link study Corrigendum to “German translation and psychometric evaluation of the Mental Health Literacy Scale (MHLS-GER) in a general population sample and in patients with acute myocardial infarction” [J. Psychiat. Res. 178 (2024) 201–209]
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1