Subsequent percutaneous breast biopsies after initial atypia diagnosis: The patient burden of long-term follow up.

IF 2.7 3区医学 Q1 SURGERY American journal of surgery Pub Date : 2024-09-27 DOI:10.1016/j.amjsurg.2024.115993

Juliet C Dalton, Samantha M Thomas, Akiko Chiba, Ton Wang, E Shelley Hwang, Jennifer K Plichta

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Abstract

Background: Breast atypia increases overall breast cancer risk, potentially necessitating future interventions. This study examines the frequency and outcomes of additional percutaneous biopsies after an atypia diagnosis.

Methods: Adult patients with breast atypia (atypical ductal hyperplasia, atypical lobular hyperplasia, lobular carcinoma in situ) at a single institution were reviewed for subsequent core needle biopsies (CNBs) and corresponding malignant outcomes.

Results: Among 432 patients, median age at diagnosis was 54.8 y. Seventy-one (71/432, 16.4 %) patients developed a breast malignancy. During a median follow-up of 7.4 y, 113 patients underwent 149 additional CNBs. Twenty-six patients (26/113, 23.0 %) had >2 additional CNBs. Approximately half (79/149, 53.0 %) of all additional CNBs occurred within 5 years after breast atypia diagnosis.

Conclusion: A considerable number of patients with breast atypia undergo additional percutaneous biopsies, especially within 5 years post-atypia diagnosis. Our study highlights the significant burden of surveillance and the need for tailored follow-up strategies.

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初次非典型诊断后的后续经皮乳腺活检：长期随访给患者带来的负担。

背景：乳腺不典型性会增加患乳腺癌的总体风险，因此今后可能有必要采取干预措施。本研究探讨了乳腺不典型增生确诊后进行额外经皮活检的频率和结果：方法：研究人员对一家医疗机构的成年乳腺非典型增生（非典型导管增生、非典型小叶增生、小叶原位癌）患者的后续核心针活检（CNB）和相应的恶性结果进行了回顾性分析：在432名患者中，确诊时的中位年龄为54.8岁。71名患者（71/432，16.4%）罹患乳腺恶性肿瘤。在中位 7.4 年的随访期间，113 名患者又接受了 149 次 CNB。26名患者（26/113，23.0%）接受了2次以上的CNB。大约一半（79/149，53.0%）的额外 CNB 发生在乳腺不典型诊断后的 5 年内：结论：相当多的乳腺不典型增生患者接受了额外的经皮活检，尤其是在确诊乳腺不典型增生后的 5 年内。我们的研究凸显了监测的巨大负担以及制定有针对性的随访策略的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.