Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential.

IF 11.7 1区医学 Q1 CELL BIOLOGY Cell Reports Medicine Pub Date : 2024-10-15 Epub Date: 2024-10-04 DOI:10.1016/j.xcrm.2024.101764

Xiaoqing Yu, Li Song, Ling Cen, Biwei Cao, Ranran Tao, Yuanyuan Shen, Daniel Abate-Daga, Paulo C Rodriguez, Jose R Conejo-Garcia, Xuefeng Wang

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Abstract

Gamma-delta T cells (γδ T cells) play a crucial role in both innate and adaptive immunity within tumors, yet their presence and prognostic value in cancer remain underexplored. This study presents a large-scale analysis of γδ T cell receptor (γδ TCR) reads from 11,000 tumor samples spanning 33 cancer types, utilizing the TRUST4 algorithm. Our findings reveal extensive diversity in γδ TCR clonality and gene expression, underscoring the potential of γδ T cells as prognostic biomarkers in various cancers. We further demonstrate the utility of TCR gamma (TRG) and delta (TRD) gene expression from standard RNA-sequencing (RNA-seq) data. This comprehensive dataset offers a valuable resource for advancing γδ T cell research, with implications for enhanced immunotherapy approaches or alternative therapeutic strategies. Additionally, our centralized database supports translational research into the therapeutic significance of γδ T cells.

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泛癌症γδTCR分析揭示了克隆型的多样性和预后潜力。

γ-δT细胞（γδ T细胞）在肿瘤的先天性免疫和适应性免疫中起着至关重要的作用，但它们在癌症中的存在和预后价值仍未得到充分探索。本研究利用 TRUST4 算法对 33 种癌症类型的 11,000 份肿瘤样本中的γδ T 细胞受体（γδ TCR）读数进行了大规模分析。我们的发现揭示了γδ TCR 克隆和基因表达的广泛多样性，强调了γδ T 细胞作为各种癌症预后生物标志物的潜力。我们进一步证明了标准 RNA 序列（RNA-seq）数据中 TCR gamma (TRG) 和 delta (TRD) 基因表达的实用性。这个全面的数据集为推进γδ T 细胞研究提供了宝贵的资源，对增强免疫疗法或替代治疗策略具有重要意义。此外，我们的中央数据库还支持对 γδ T 细胞治疗意义的转化研究。

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来源期刊

Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

15.00

自引率

1.40%

发文量

231

审稿时长

40 days

期刊介绍： Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.