Catalyzing the future: recent advances in chemical synthesis using enzymes

IF 6.9 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Current Opinion in Chemical Biology Pub Date : 2024-10-05 DOI:10.1016/j.cbpa.2024.102536
Julia C. Reisenbauer , Kathleen M. Sicinski , Frances H. Arnold
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Abstract

Biocatalysis has the potential to address the need for more sustainable organic synthesis routes. Protein engineering can tune enzymes to perform in cascade reactions and for efficient synthesis of enantiomerically enriched compounds, using both natural and new-to-nature reaction pathways. This review highlights recent achievements in biocatalysis, especially the development of novel enzymatic syntheses to access versatile small molecule intermediates and complex biomolecules. Biocatalytic strategies for the degradation of persistent pollutants and approaches for biomass valorization are also discussed. The transition of chemical synthesis to a greener future will be accelerated by implementing enzymes and engineering them for high performance and new activities.
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催化未来:利用酶进行化学合成的最新进展。
生物催化有可能满足对更具可持续性的有机合成途径的需求。蛋白质工程可以调整酶,使其在级联反应中发挥作用,并利用天然反应途径和新自然反应途径高效合成对映体丰富的化合物。本综述重点介绍生物催化领域的最新成就,特别是开发新型酶合成技术,以获得多功能小分子中间体和复杂生物大分子。此外,还讨论了降解持久性污染物的生物催化策略和生物质增值的方法。通过使用酶和对酶进行高性能和新活动的工程设计,将加速化学合成向更绿色的未来过渡。
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来源期刊
Current Opinion in Chemical Biology
Current Opinion in Chemical Biology 生物-生化与分子生物学
CiteScore
13.30
自引率
1.30%
发文量
113
审稿时长
74 days
期刊介绍: COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.
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