Practice Patterns of Biologics Prescriptions and Surgery in Chronic Rhinosinusitis With Nasal Polyps.

IF 2.5 3区 医学 Q1 OTORHINOLARYNGOLOGY American Journal of Rhinology & Allergy Pub Date : 2024-10-07 DOI:10.1177/19458924241287959
Firas K Almarri, Saad Algahtani, Ghassan Alokby, Muteb Alanazi, Saad Alsaleh
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Abstract

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) remains challenging to manage effectively, with high symptom recurrence rates and significant impacts on quality of life, prompting a need to evaluate the real-world use of biologics and optimize treatment strategies.

Objective: To assess the real-world application and perspectives of American Rhinologic Society (ARS) members on biologic treatments and surgical interventions for CRSwNP, focusing on clinical practice patterns, adoption of biologics, and their impact on surgical practices.

Methods: A standardized questionnaire evaluated clinical practice patterns of biologics prescriptions and surgery in treating CRSwNP between July 2022 and August 2023. Data collected from 162 ARS members were analyzed.

Results: Of 162 participants, a substantial majority (95.06%, n = 154) reported prescribing biologics in their practice. Notably, 45.45% (n = 70) found biologics easily accessible, although accessibility challenges remained for some. The impact of biologics on surgical practices was significant, with 36.36% (n = 56) observing a marked reduction in revision sinus surgeries. Among the participants, 47.16% (n = 71) agreed that aspirin-exacerbated respiratory disease (AERD) was the highest phenotype that tended to increase the possibility of biological treatment by more than 20%. Adopting Patient-Reported Outcome Measures (PROMs) was prevalent, with 57.79% (n = 89) utilizing them in patient management.

Conclusion: The study highlights the evolving landscape in managing CRSwNP, with a marked trend toward integrating biological treatments into clinical practice. It underscores the necessity for continued research, updates to clinical guidelines, and enhanced practitioner education to optimize treatment outcomes for CRSwNP patients.

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慢性鼻窦炎伴鼻息肉患者的生物制剂处方和手术实践模式。
背景:伴有鼻息肉的慢性鼻炎(CRSwNP)的有效治疗仍具有挑战性,症状复发率高且对生活质量有重大影响,因此需要评估生物制剂的实际使用情况并优化治疗策略:目的:评估美国鼻科学会(ARS)会员在现实世界中对 CRSwNP 的生物制剂治疗和手术干预的应用情况和观点,重点关注临床实践模式、生物制剂的采用及其对手术实践的影响:一份标准化问卷调查评估了 2022 年 7 月至 2023 年 8 月期间治疗 CRSwNP 的生物制剂处方和手术的临床实践模式。对从 162 名 ARS 成员处收集的数据进行了分析:结果:在162名参与者中,绝大多数(95.06%,n = 154)报告在其临床实践中开具生物制剂处方。值得注意的是,45.45%(n = 70)的人认为生物制剂很容易获得,尽管有些人在获得生物制剂方面仍面临挑战。生物制剂对外科手术的影响很大,36.36%(n = 56)的人发现鼻窦翻修手术明显减少。在参与者中,47.16%(n = 71)的人认为阿司匹林加重的呼吸系统疾病(AERD)是最高的表型,往往会使生物制剂治疗的可能性增加 20% 以上。采用患者报告结果衡量标准(PROMs)的情况很普遍,57.79%(n = 89)的患者在患者管理中采用了该衡量标准:本研究强调了 CRSwNP 管理中不断变化的情况,将生物疗法纳入临床实践是一个明显的趋势。它强调了继续研究、更新临床指南和加强从业人员教育以优化 CRSwNP 患者治疗效果的必要性。
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来源期刊
CiteScore
5.60
自引率
11.50%
发文量
82
审稿时长
4-8 weeks
期刊介绍: The American Journal of Rhinology & Allergy is a peer-reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials, and review articles.
期刊最新文献
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